Safety profile and pharmacokinetics of an inhaled GATA-3-specific DNAzyme in a phase Ib study in patients with stable allergic asthma

被引:0
|
作者
Hohlfeld, Jens [1 ]
Lueer, Katrin [1 ]
Krug, Norbert [1 ]
Turowska, Agnieszka [2 ]
Renz, Harald [3 ]
Garn, Holger [3 ]
Homburg, Ursula [2 ]
机构
[1] Fraunhofer ITEM, Clin Airway Res, Hannover, Germany
[2] GmbH, Sterna Biol, Marburg, Germany
[3] Univ Marburg, Clin Chem & Mol Diagnost, Marburg, Germany
关键词
Asthma; -; management; Pharmacology; Anti-inflammatory;
D O I
暂无
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
1916
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Safety Profile And Pharmacokinetics Of An Inhaled Gata-3-Specific Dnazyme In Phase I Clinical Trials In Healthy Subjects And Patients With Allergic Asthma
    Homburg, U.
    Bille, J.
    Kuhlmann, J.
    Turowska, A.
    Renz, H.
    Garn, H.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2013, 187
  • [2] Safety profile and pharmacokinetics of an inhaled GATA-3-specific DNAzyme in a first-in man study in healthy subjects
    Timmer, Wolfgang
    Kutz, Klaus
    Schlueter, Gerhard
    Seitz, Friedeborg
    Wannenwetsch, Uwe
    Kuhlmann, Jens
    Stauss-Grabo, Manuela
    Zensi, Anja
    Schmidt, Oliver
    Breipohl, Gerhard
    Renz, Harald
    Bille, Joachim
    Homburg, Ursula
    Garn, Holger
    EUROPEAN RESPIRATORY JOURNAL, 2012, 40
  • [3] Safety profile and pharmacokinetics of SB010, an inhaled GATA-3-specific DNAzyme, in phase I clinical trials in healthy and asthmatic subjects
    Homburg, Ursula
    Turowska, Agnieszka
    Kuhlmann, Jens
    Mueller, Anke
    Renz, Jonas
    Bille, Joachim
    Renz, Harald
    Garn, Holger
    EUROPEAN RESPIRATORY JOURNAL, 2013, 42
  • [4] Safety profile and pharmacokinetics of SB010, an inhaled GATA-3-specific DNAzyme, in phase I clinical trials in healthy and asthmatic subjects
    Homburg, U.
    Turowska, A.
    Mueller, A.
    Kuhlmann, J.
    Renz, J.
    Bille, J.
    Renz, H.
    Garn, H.
    ALLERGY, 2013, 68 : 40 - 40
  • [5] Effective prevention and therapy of experimental allergic asthma using a GATA-3-specific DNAzyme
    Sel, Serdar
    Wegmann, Michael
    Dicke, Tanja
    Sel, Sarper
    Henke, Wolfgang
    Yildirim, Ali Oe.
    Renz, Harald
    Garn, Holger
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2008, 121 (04) : 910 - 916
  • [6] Gata-3-specific dnazyme as an appraoch for asthma-therapy - Abstracts
    Dicke, T.
    Wegmann, M.
    Sel, S.
    Renz, H.
    Garn, H.
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2007, 119 (01) : S1 - S1
  • [7] GATA-3-specific DNAzyme - A novel approach for stratified asthma therapy
    Garn, Holger
    Renz, Harald
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2017, 47 (01) : 22 - 30
  • [8] Advantageous toxicity profile of an inhaled GATA-3-specific DNAzyme intended for anti-inflammatory treatment of Th2-driven asthma
    Fuhst, Rainer
    Runge, Frank
    Buschmann, Jochen
    Praechter, Christiane
    von Erichsen, Jasmin
    Turowska, Agnieszka
    Hoymann, Heinz-Gerd
    Mueller, Meike
    Pohlmann, Gerhard
    Sewald, Katherina
    Ziemann, Christina
    Schlueter, Gerhard
    Garn, Holger
    EUROPEAN RESPIRATORY JOURNAL, 2012, 40
  • [9] Toxicity profile of the GATA-3-specific DNAzyme hgd40 after inhalation exposure
    Fuhst, Rainer
    Runge, Frank
    Buschmann, Jochen
    Ernst, Heinrich
    Praechter, Christiane
    Hansen, Tanja
    von Erichsen, Jasmin
    Turowska, Agnieszka
    Hoymann, Heinz-Gerd
    Mueller, Meike
    Pohlmann, Gerhard
    Sewald, Katherina
    Ziemann, Christina
    Schlueter, Gerhard
    Garn, Holger
    PULMONARY PHARMACOLOGY & THERAPEUTICS, 2013, 26 (02) : 281 - 289
  • [10] Anti-inflammatory effects of a human GATA-3-specific DNAzyme in different mouse models of allergic airway inflammation
    Marsh, L.
    Turowska, A.
    Hagner-Benes, S.
    Dicke, T.
    Conrad, M.
    Renz, H.
    Garn, H.
    ALLERGY, 2011, 66 : 25 - 25