Development of SH2 domain proteomimetics as potent disruptors of oncogenic Stat3:Stat3 dimerization

被引:0
|
作者
Drewry, Joel A.
Gunning, Patrick T.
机构
[1] Univ Toronto, Dept Chem, Toronto, ON M5S 1A1, Canada
[2] Univ Toronto, Dept Chem & Phys Sci, Mississauga, ON L5L 1C6, Canada
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
159-MEDI
引用
收藏
页数:1
相关论文
共 50 条
  • [1] Novel STAT3 Inhibitors Targeting STAT3 Dimerization by Binding to the STAT3 SH2 Domain
    Hua, Yaping
    Yuan, Xing
    Shen, Yun-heng
    Wang, Jinxin
    Azeem, Waqas
    Yang, Shuo
    Gade, Alexandra
    Lellahi, Seyed Mohammad
    oyan, Anne Margrete
    Ke, Xisong
    Zhang, Wei-dong
    Kalland, Karl-Henning
    FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [2] The Role of the STAT3 SH2/TA Flexible Loop Domain in STAT3 Signaling
    Hubbard, Nicholas
    Yamazaki, Takashi
    Anover-Sombke, Stephanie
    Rylaarsdam, Stacey
    Ochs, Hans
    Torgerson, Troy R.
    JOURNAL OF CLINICAL IMMUNOLOGY, 2012, 32 (02) : 389 - 389
  • [3] On modeling peptidomimetics in complex with the SH2 domain of Stat3
    Dhanik, Ankur
    McMurray, John S.
    Kavraki, Lydia
    2011 ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC), 2011, : 3229 - 3232
  • [4] Structural Implications of STAT3 and STAT5 SH2 Domain Mutations
    de Araujo, Elvin D.
    Orlova, Anna
    Neubauer, Heidi A.
    Bajusz, David
    Seo, Hyuk-Soo
    Dhe-Paganon, Sirano
    Keseru, Gyorgy M.
    Moriggl, Richard
    Gunning, Patrick T.
    CANCERS, 2019, 11 (11)
  • [5] Cytosolic delivery of peptidic STAT3 SH2 domain inhibitors
    Cerulli, Robert A.
    Shehaj, Livia
    Tosic, Isidora
    Jiang, Kevin
    Wang, Jing
    Frank, David A.
    Kritzer, Joshua A.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2020, 28 (12)
  • [6] Novel STAT3 inhibitors targeting the STAT3 dimerization
    Hua, Yaping
    Azeem, Waqas
    Oyan, Anne Margrete
    Kalland, Karl-Henning
    CANCER RESEARCH, 2022, 82 (12)
  • [7] A Cell-permeable Stat3 SH2 Domain Mimetic Inhibits Stat3 Activation and Induces Antitumor Cell Effects in Vitro
    Zhao, Wei
    Jaganathan, Soumya
    Turkson, James
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (46) : 35855 - 35865
  • [8] Developing phosphotyrosine- mimicking peptides for the inhibition of the STAT3 SH2 domain
    Cerulli, Robert
    Kritzer, Joshua
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 256
  • [9] A cell-permeable Stat3 SH2 domain mimetic inhibitor of Stat3 activation inhibits growth of human breast tumor xenog rafts
    Zhao, Wei
    Jaganathan, Soumya
    Zhang, Xiaolei
    Turkson, James
    CANCER RESEARCH, 2011, 71
  • [10] Identification of New Shikonin Derivatives as Antitumor Agents Targeting STAT3 SH2 Domain
    Qiu, Han-Yue
    Zhu, Xiang
    Luo, Yue-Lin
    Lin, Hong-Yan
    Tang, Cheng-Yi
    Qi, Jin-Liang
    Pang, Yan-Jun
    Yang, Rong-Wu
    Lu, Gui-Hua
    Wang, Xiao-Ming
    Yang, Yong-Hua
    SCIENTIFIC REPORTS, 2017, 7