Expression of the Long Noncoding RNA GAS5 Correlates with Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease

被引：32

作者：

Han, Man-Hoon ^{[1
]}

Lee, Jee Hyun ^{[2
]}

Kim, Gyeonghwa ^{[2
]}

Lee, Eunhye ^{[2
]}

Lee, Yu Rim ^{[3
]}

Jang, Se Young ^{[3
]}

Lee, Hye Won ^{[4
]}

Chun, Jae Min ^{[5
]}

Han, Young Seok ^{[5
]}

Yoon, Jun Sik ^{[6
]}

Kang, Min Kyu ^{[7
]}

Lee, Won Kee ^{[8
,9
]}

Kweon, Young Oh ^{[3
]}

Tak, Won Young ^{[3
]}

Park, Soo Young ^{[3
]}

Park, Jung Gil ^{[7
]}

Hur, Keun ^{[2
]}

机构：

[1] Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Pathol, Daegu 41944, South Korea

[2] Kyungpook Natl Univ, Sch Med, Cell & Matrix Res Inst, Dept Biochem & Cell Biol, Daegu 41944, South Korea

[3] Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Internal Med, Daegu 41944, South Korea

[4] Keimyung Univ, Dongsan Med Ctr, Sch Med, Dept Pathol, Daegu 42601, South Korea

[5] Kyungpook Natl Univ, Kyungpook Natl Univ Hosp, Sch Med, Dept Surg, Daegu 41944, South Korea

[6] Inje Univ, Busan Paik Hosp, Dept Internal Med, Coll Med, Busan 74392, South Korea

[7] Yeungnam Univ, Coll Med, Dept Internal Med, Daegu 42415, South Korea

[8] Kyungpook Natl Univ, Med Res Collaborat Ctr KNUH, Daegu 42415, South Korea

[9] Kyungpook Natl Univ, Sch Med, Daegu 42415, South Korea

来源：

GENES | 2020年 / 11卷 / 05期

关键词：

noncoding RNA; biomarker; lncRNA GAS5; nonalcoholic fatty liver disease; liver fibrosis; CANCER; HOTAIR; LINCRNA-P21; MORTALITY; MECHANISM; DIAGNOSIS; BIOMARKER; FEATURES; CELLS;

D O I：

10.3390/genes11050545

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Background: Advanced liver fibrosis is the most important prognostic factor in nonalcoholic fatty liver disease (NAFLD). The long noncoding RNA (lncRNA), growth arrest-specific transcript 5 (GAS5), is associated with the inhibition of liver fibrogenesis, and its levels are decreased in cirrhotic liver. Methods: We analyzed 51 patients with NAFLD, the diagnosis of which was confirmed by liver biopsy. Expression of GAS5 in both the liver and plasma of the patients was analyzed using a quantitative real-time polymerase chain reaction according to the fibrosis stage. Results: Plasma GAS5 expression was significantly higher in patients with advanced fibrosis than in those without. As the fibrosis progressed, GAS5 expression in plasma increased, with the exception of that in cirrhotic livers. Plasma levels of GAS5 were lower in patients with cirrhosis than in those with advanced fibrosis. Conclusion: Elevated circulating levels of the lncRNA GAS5 are associated with the progression of liver fibrosis prior to the development of cirrhosis.

引用

页数：10

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