Practical enantiospecific synthesis of RPR 111905: A novel non-peptide substance P antagonist

被引：10
|
作者：
Mutti, S
Daubie, C
Malpart, J
Radisson, X
机构：
[1] Rhone-Poulenc Rorer - Ctr. de R., Chemical Process - 13, Quai Jules Guesde, 94403 Vitry sur Seine
来源：
TETRAHEDRON LETTERS | 1996年 / 37卷 / 48期
关键词：
D O I：
10.1016/S0040-4039(96)02017-5
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of enantiomerically pure RPR 111905 was achieved in twelve steps with an overall yield of 6.9%. The synthetic strategy was based on a Diels-Alder reaction to generate the bicyclic framework and the asymmetry was introduced by resolution. Copyright (C) 1996 Elsevier Science Ltd
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收藏
页码：8743 / 8746
页数：4
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