The role of vitamin D and P2X7R in multiple sclerosis

被引：5
|
作者：
Voo, Veronica Tsin Fong [1 ,2 ]
O'Brien, Terence [2 ,3 ]
Butzkueven, Helmut [2 ]
Monif, Mastura [1 ,2 ,3 ]
机构：
[1] Univ Melbourne, Dept Physiol, Melbourne, Vic, Australia
[2] Monash Univ, Dept Neurosci, Melbourne, Vic, Australia
[3] Melbourne Hlth, Dept Neurol, Melbourne, Vic, Australia
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2019年 / 330卷
关键词：
Multiple sclerosis; Neuroinflammation; P2X7R; Vitamin D; Innate immunity; Monocytes; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; TOLL-LIKE RECEPTORS; P2X(7) RECEPTOR; T-CELLS; HUMAN MONOCYTES; FUNCTIONAL-CHARACTERIZATION; 25-HYDROXYVITAMIN-D LEVELS; DOSE CHOLECALCIFEROL; PURINERGIC RECEPTOR; CEREBROSPINAL-FLUID;
D O I：
10.1016/j.jneuroim.2019.03.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Multiple sclerosis (MS) is characterized by neuroinflammatory infiltrates and central nervous system demyelination. In the neuroinflammatory foci of MS there is increased expression of a purinergic receptor, P2X7R. Although implicated in the neuroinflammation, the exact role of P2X7R in the context of MS is unclear and forms the basis of this review. In this review, we also introduce the immunopathologies and inflammatory processes in MS, with a focus on P2X7R and the possible immunomodulatory role of vitamin D deficiency in this setting.
引用
收藏
页码：159 / 169
页数：11
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