Preliminary evaluation of pharmacological properties of some xanthone derivatives

被引：46
|
作者：
Marona, Henryk [1 ]
Szkaradek, Natalia [1 ,2 ]
Rapacz, Anna [3 ]
Filipek, Barbara [3 ,4 ]
Dybala, Malgorzata [5 ]
Siwek, Agata [5 ]
Cegla, Marek [2 ]
Szneler, Edward [6 ]
机构：
[1] Jagiellonian Univ, Coll Med, Fac Pharm, Dept Technol & Biotechnol Drugs, PL-30688 Krakow, Poland
[2] Jagiellonian Univ, Coll Med, Fac Pharm, Dept Organ Chem, PL-30688 Krakow, Poland
[3] Jagiellonian Univ, Coll Med, Fac Pharm, Dept Pharmacodynam, PL-30688 Krakow, Poland
[4] Jagiellonian Univ, Coll Med, Fac Pharm, Lab Pharmacol Screening, PL-30688 Krakow, Poland
[5] Jagiellonian Univ, Coll Med, Fac Pharm, Lab Pharmacobiol,Dept Cytobiol, PL-30688 Krakow, Poland
[6] Jagiellonian Univ, Fac Chem, PL-30688 Krakow, Poland
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2009年 / 17卷 / 03期
关键词：
Xanthones; Antiarrhythmic; hypotensive and anticonvulsive activities; Radioligand-binding assay; AMINOALKANOLIC DERIVATIVES; HYPOTENSIVE PROPERTIES; PROPRANOLOL; DRUGS;
D O I：
10.1016/j.bmc.2008.12.031
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A series of xanthone derivatives were synthesized and examined for electrocardiographic, antiarrhythmic, hypotensive and anticonvulsant activities as well as for alpha(1)- and beta(1)- adrenergic binding affinities. Among the investigated compounds, some of them exhibited significant antiarrhythmic and/or hypotensive activity. The data obtained via receptor binding assay are in agreement with pharmacological results and could explain antiarrhythmic and/or hypotensive activity of the newly synthesized structures. (c) 2008 Elsevier Ltd. All rights reserved.
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收藏
页码：1345 / 1352
页数：8
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