Adenovirus-mediated expression of BmK CT suppresses growth and invasion of rat C6 glioma cells

被引：13

作者：

Du, Jun ^{[1
]}

Fu, Yuejun ^{[1
]}

Wang, Jianing ^{[2
]}

Liang, Aihua ^{[1
]}

机构：

[1] Shanxi Univ, Inst Biotechnol, Minist Educ, Key Lab Chem Biol & Mol Engn, Taiyuan 030006, Peoples R China

[2] Hubei Univ Med, Inst Clin Med, Shiyan 442000, Peoples R China

来源：

BIOTECHNOLOGY LETTERS | 2013年 / 35卷 / 06期

基金：

中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

Adenovirus; BmK CT; Gliomas; Scorpion toxin; CHLOROTOXIN-LIKE PEPTIDE; GENE-THERAPY; CHINESE SCORPION; TUMOR-GROWTH; CLONING; KARSCH; VENOM;

D O I：

10.1007/s10529-013-1167-9

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

BmK CT, one of the key toxins in the venom of the scorpion, Buthus martensii Karsch, can interact specifically with glioma cells as a chloride channel blocker and inhibit the invasion and migration of those cells via MMP-2. A recombinant adenovirus, Ad-BmK CT, was constructed and characterized by in vitro and in vivo studies, using MTT cytotoxicity assay and the glioma C6/RFP (red fluorescence protein)/BALB/c allogeneic athymic nude mice model, respectively. The adenovirus-mediated expression of BmK CT displayed a high activity in suppressing rat C6 glioma cells growth and invasion thereby suggesting that this recombinant adenovirus may be a powerful method for treating glioblastoma.

引用

页码：861 / 870

页数：10

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