The Fluid Mechanics of Cancer and Its Therapy

被引：103
|
作者：
Koumoutsakos, Petros [1 ]
Pivkin, Igor [2 ]
Milde, Florian [1 ]
机构：
[1] ETH, Computat Sci & Engn Lab, CH-8092 Zurich, Switzerland
[2] Univ Svizzera Italiana, Inst Computat Sci, CH-6900 Lugano, Switzerland
来源：
ANNUAL REVIEW OF FLUID MECHANICS, VOL 45 | 2013年 / 45卷
关键词：
tumor; blood flow; angiogenesis; nanoparticles; CIRCULATING TUMOR-CELLS; MULTIPARTICLE ADHESIVE DYNAMICS; BLOOD-FLOW; INTUSSUSCEPTIVE ANGIOGENESIS; SHEAR-STRESS; IN-VIVO; ANTIANGIOGENIC THERAPY; GENOMIC INSTABILITY; INTERSTITIAL FLOW; MMP-9; EXPRESSION;
D O I：
10.1146/annurev-fluid-120710-101102
中图分类号：
O3 [力学];
学科分类号：
08 ; 0801 ;
摘要：
Fluid mechanics is involved in the growth, progression, metastasis, and therapy of cancer. Blood vessels transport oxygen and nutrients to cancerous tissues, provide a route for metastasizing cancer cells to distant organs, and deliver drugs to tumors. The irregular and leaky tumor vasculature is responsible for increased interstitial pressure in the tumor microenvironment, whereas multiscale flow-structure interaction processes control tumor growth, metastasis, and nanoparticle-mediated drug delivery. We outline these flow-mediated processes, along with related experimental and computational methods for the diagnosis, predictive modeling, and therapy of cancer.
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页码：325 / 355
页数：31
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