α-fetoprotein expression in a dedifferentiated liposarcoma

被引：4
|
作者：
Bosco, M
Allia, E
Coindre, JM
Odasso, C
Pagani, A
Pacchioni, D
机构：
[1] Univ Turin, Dept Biomed Sci & Human Oncol, I-10126 Turin, Italy
[2] Inst Bergonie, Dept Pathol, F-33076 Bordeaux, France
[3] Univ Turin, Dept Gen Surg, I-10126 Turin, Italy
[4] Osped Civile Pinerolo, Dept Pathol, I-10064 Pinerolo, Italy
来源：
VIRCHOWS ARCHIV | 2006年 / 448卷 / 04期
关键词：
dedifferentiated liposarcoma; alpha-fetoprotein; ectopic production;
D O I：
10.1007/s00428-006-0151-3
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Extremely rare cases of paraneoplastic syndromes or ectopic production of proteins associated with liposarcoma are reported in literature. We describe a unique case of relapsing retroperitoneal dedifferentiated liposarcoma with biochemical, immunohistochemical, and molecular evidence of alpha-fetoprotein (AFP) ectopic production. The lesion was associated to elevated AFP plasma levels that subsided after tumor removal. Immunohistochemical studies showed AFP production by a minority of tumor cells and reverse transcriptase polymerase chain reaction confirmed AFP mRNA expression. Finding of MDM2 and CDK4 iperexpression by immunohistochemistry confirmed the diagnosis of dedifferentiated liposarcoma.
引用
收藏
页码：517 / 520
页数：4
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