Synthesis, Crystal Structure and Neuroprotection of a Novel Isoflavone Sulfonamide Compound

4',7-Dimethoxy-N-methylisoflavone-3'-sulfonamide (3) was synthesized by a two step synthesis method and characterized via IR and 1H NMR. Its chemical structure was determined by X-ray single-crystal diffraction. It crystallizes in monoclinic, space group C2/c with a = 27.677(13), b = 10.490(5), c = 13.982(7) angstrom, beta= 118.781(9)degrees, V = 3558(3) angstrom(3), Z = 8, F(000) = 1568, D-c, = 1.401 Mg/m(3), M-r = 375.39, mu = 0.217 mm(-1), A = 0.71073 A, the final R = 0.0436 and wR.0.0910 for 3168 observed reflections with I> 2 sigma(I). The compound was studied subsequently for the potent neuroprotective activity, and showed effects against oxygen-glucose deprivation injury in PC12 cells in a dose-dependent manner (protection: 42.5% at 100 mu g.mL(-1), 35.1% at 10 mu g.mL(-1) and 22.5% at 1 mu g-mL(-1)).