One-step assembly of carbamoyl-substituted heteroannelated [1,4]thiazepines

被引：43
|
作者：
Ilyn, AP
Loseva, MV
Vvedensky, VY
Putsykina, EB
Tkachenko, SE
Kravchenko, DV
Khvat, AV
Krasavin, MY
Ivachtchenko, AV [1 ]
机构：
[1] Chem Divers Res Inst, Dept Organ Chem, Chimki 114401, Moscow Reg, Russia
[2] ChemDiv Inc, San Diego, CA 92121 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2006年 / 71卷 / 07期
关键词：
D O I：
10.1021/jo052640w
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We present a convenient synthesis of novel heteroaryl-fused 3-oxo-1,4-thiazepine-5-carboxamides and 5-oxo-1,4-thiazepine-3-carboxainides using a modification of four-component Ugi condensation. We demonstrate the usefulness and versatility of the developed approach for the synthesis of variously substituted compounds and discuss the scope and limitations of the chemistry involved.
引用
收藏
页码：2811 / 2819
页数：9
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