Ruthenium-Catalyzed C-H Functionalization of Arylpyrazoles: Regioselective Acylation with Acid Chlorides

被引：60
|
作者：
Liu, Po Man [1 ]
Frost, Christopher G. [1 ]
机构：
[1] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 22期
基金：
英国工程与自然科学研究理事会;
关键词：
DIRECT ARYLATIONS; BOND ACTIVATION; CARBOXYLIC-ACIDS; CARBON-CARBON; ARENES; ALKYLATION; HYDROARYLATION; CARBONYLATION; PHENYLAZOLES; ALKYNES;
D O I：
10.1021/ol402936c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A ruthenium-catalyzed C-H acylation of arylpyrazoles with a variety of acyl chlorides is described. The acylation reaction exhibits good regioselectivity and both aromatic and aliphatic acyl chlorides can be effectively coupled to the arylpyrazoles at the ortho-position.
引用
收藏
页码：5862 / 5865
页数：4
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