Pharmacokinetics and Applications of Magnetic Nanoparticles

被引：2

作者：

Mao, Runyi ^{[1
]}

Wang, Jing ^{[2
]}

Pei, Jiao ^{[3
]}

Wu, Songtao ^{[1
]}

Feng, Jie ^{[1
]}

Lin, Yunfeng ^{[1
]}

Cai, Xiaoxiao ^{[1
]}

机构：

[1] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China

[2] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Stomatol, Shanghai 200092, Peoples R China

[3] Sichuan Univ, West China Sch Publ Hlth, Dept Med Stat, Chengdu 610064, Sichuan Provinc, Peoples R China

来源：

CURRENT DRUG METABOLISM | 2013年 / 14卷 / 08期

基金：

国家教育部博士点专项基金资助; 中国国家自然科学基金;

关键词：

Nanomaterial; magnetic nanoparticles (MNPs); drug delivery system; hyperthermia; cancer; targeting; SUPERPARAMAGNETIC IRON-OXIDE; WHOLE-BODY HYPERTHERMIA; TEMPERATURE DISTRIBUTION; EFFICIENT DETECTION; SPHERICAL TISSUE; CANCER-TREATMENT; DRUG-DELIVERY; CELLS; CONTRAST; STABILIZATION;

D O I：

10.2174/138920021131400109

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nanomaterials possess enormous potential for biomedical applications, while some of the most promising nanomaterials currently under investigation demonstrate prolonged tissue retention and contain heavy metals. This article investigates the pharmacokinetics of magnetic nanoparticles (MNPs) to help identify promising candidates with optimal pharmacokinetics and clearance from the body for biomedical use and synthesize nanomaterials ideal for biomedical use. The term 'magnetic nanoparticles' (MNPs) refers to nanoparticles with ferromagnetism. Such nanoparticles have special characteristics, and many in the field of biological field have undertaken research involving, e. g., immobilized enzymes and proteins, biological cells, macromolecular separation, drug carriers, and targeted, immune, biological sensors.

引用

页码：872 / 878

页数：7

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