Grayanoids from the Ericaceae family: structures, biological activities and mechanism of action

被引：89
|
作者：
Li, Yong [1 ,2 ]
Liu, Yun-Bao [1 ,2 ]
Yu, Shi-Shan [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China
[2] Peking Union Med Coll, Beijing 100050, Peoples R China
来源：
PHYTOCHEMISTRY REVIEWS | 2013年 / 12卷 / 02期
关键词：
Grayanoid; Diterpenoid; Structure; Bioactivity; GRAYANANE DITERPENOIDS; MOLECULAR-STRUCTURE; PIERIS-JAPONICA; SODIUM-CHANNEL; RHODODENDRON-JAPONICUM; GRAYANOTOXIN-VII; MINOR DITERPENE; POINT-MUTATIONS; MAD HONEY; D-RING;
D O I：
10.1007/s11101-013-9299-z
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Grayanoids, occurring exclusively in Ericaceae plants, are well-known highly toxic components from the genera Rhododendron, Pieris, Leucothoe, Craibiodendron, Lyonia, Kalmia, etc. Grayanoids have been the topic of research in many phytochemical and pharmacological laboratories due to their complex structures and fascinating bioactivities. This review, citing 100 references, summarises their chemistry, including the total synthesis and bioactivity of grayanoids isolated from the Ericaceae family in the last five decades, to illustrate the chemo-diversity and biological significance of these diterpenoids.
引用
收藏
页码：305 / 325
页数：21
相关论文
共 50 条
  • [1] Grayanoids from the Ericaceae family: structures, biological activities and mechanism of action
    Yong Li
    Yun-Bao Liu
    Shi-Shan Yu
    Phytochemistry Reviews, 2013, 12 : 305 - 325
  • [2] An overview of grayanane diterpenoids and their biological activities from the Ericaceae family in the last seven years
    Li, Chun-Huan
    Zhang, Jia-Yao
    Zhang, Xiu-Yun
    Li, Sheng-Hong
    Gao, Jin-Ming
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 166 : 400 - 416
  • [3] Chemical studies on Ericaceae plants -: Part 2 -: Grayanoids from Pieris formosa
    Ding, LQWBY
    Qin, GW
    Lin, G
    Cheng, KF
    PHYTOCHEMISTRY, 1998, 49 (07) : 2045 - 2048
  • [4] THE CHEMISTRY, BIOLOGICAL ACTIVITIES AND MECHANISM OF ACTION OF (-) CLAUSENAMIDE
    Zhang, J.
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2014, 115 : 152 - 152
  • [5] Structures, Biological Activities and Preliminary Mechanism of Action Studies of Harmful Algal Bloom Toxins from Karlodinium sp.
    Waters, A. L.
    Oh, J.
    Peng, J.
    Place, A. R.
    Hamann, M. T.
    PLANTA MEDICA, 2013, 79 (10) : 822 - 822
  • [6] Structures, Biological Activities and Action Mechanisms of Secondary Metabolites from Soybean: A Review
    Meng, Xinjing
    Yang, Xu
    Meng, Deshang
    Wang, Menghan
    Wang, Lei
    Liu, Zhenhua
    Shipin Kexue/Food Science, 2024, 45 (20): : 35 - 47
  • [7] Phytochemicals and Biological Activities of Poisonous Genera of Ericaceae in China
    Wang, Xiaohong
    Jiang, Rui
    Liu, Zizhen
    Liu, Weirui
    Xie, Meng
    Wei, Shengli
    She, Gaimei
    NATURAL PRODUCT COMMUNICATIONS, 2014, 9 (03) : 427 - 442
  • [8] Biological Activities of Plant Polysaccharides, Mechanism of Action and Biomedical Applications
    Govindarajan, S.
    Noor, Ayesha
    RESEARCH JOURNAL OF BIOTECHNOLOGY, 2021, 16 (07): : 255 - 272
  • [9] Coumarins as Potential Antiprotozoal Agents: Biological Activities and Mechanism of Action
    Elkin Jose Torres Sierra
    Cleydson Finotti Cordeiro
    Livia de Figueiredo Diniz
    Ivo Santana Caldas
    Jamie Anthony Hawkes
    Diogo Teixeira Carvalho
    Revista Brasileira de Farmacognosia, 2021, 31 : 592 - 611
  • [10] Mechanism of action and the biological activities of Nigella sativa oil components
    Silva, Andre Filipe C.
    Haris, Parvez I.
    Serralheiro, Maria Luisa
    Pacheco, Rita
    FOOD BIOSCIENCE, 2020, 38
12345