Trafficking of NMDA receptors during status epilepticus: Therapeutic implications

被引：48

作者：

Wasterlain, Claude G. ^{[1
,2
,3
]}

Naylor, David E. ^{[1
,2
,4
]}

Liu, Hantao ^{[1
,2
]}

Niquet, Jerome ^{[1
,2
]}

Baldwin, Roger ^{[1
]}

机构：

[1] Vet Adm Greater Los Angeles Healthcare Syst, Dept Neurol, West Los Angeles, CA USA

[2] UCLA Brain Res Inst, West Los Angeles, CA USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, West Los Angeles, CA USA

[4] Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, West Los Angeles, CA USA

来源：

EPILEPSIA | 2013年 / 54卷

关键词：

NMDA receptor; Receptor trafficking; Status epilepticus; Acute seizures; Cholinergic seizures; Epilepsy; Monotherapy; Hippocampus; SUSTAINING STATUS EPILEPTICUS; EPILEPTOGENESIS; ANTAGONISTS;

D O I：

10.1111/epi.12285

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We used two models of status epilepticus (SE) to study trafficking of N-methyl-d-aspartate (NMDA) receptors. SE is associated with increased surface expression of NR1 subunits of NMDA receptors, and with an increase of NMDA synaptic and extrasynaptic currents suggesting an increase in number of functional NMDA receptors on dentate granule cells. The therapeutic implications of these results are discussed.

引用

页码：78 / 80

页数：3

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