A multilateral effort to develop DNA vaccines against falciparum malaria

被引：39
|
作者：
Kumar, S [1 ]
Epstein, JE
Richie, TL
Nkrumah, FK
Soisson, L
Carucci, DJ
Hoffman, SL
机构：
[1] USN, Malaria Program, Med Res Ctr, Silver Spring, MD 20910 USA
[2] Noguchi Mem Inst Med Res, Accra, Ghana
[3] US Agcy Int Dev, Malaria Vaccine Dev Program, Washington, DC 20523 USA
[4] Celera Genom, Rockville, MD 20850 USA
来源：
TRENDS IN PARASITOLOGY | 2002年 / 18卷 / 03期
关键词：
D O I：
10.1016/S1471-4922(01)02207-3
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Scientists from several organizations worldwide are working together to develop a multistage, multigene DNA-based vaccine against Plasmodium falciparum malaria. This collaborative vaccine development effort is named Multi-Stage DNA-based Malaria Vaccine Operation. An advisory board of international experts in vaccinology, malariology and field trials provides the scientific oversight to support the operation. This article discusses the rationale for the approach, underlying concepts and the pre-clinical development process, and provides a brief outline of the plans for the clinical testing of a multistage, multiantigen malaria vaccine based on DNA plasmid immunization technology.
引用
收藏
页码：129 / 135
页数：7
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