Validation of an HPLC analytical method for determination of pancuronium bromide in pharmaceutical injections

被引：9
|
作者：
Lopez Garcia, Pedro [1 ]
Pereira Gomes, Fabio [1 ]
Ines Rocha, Maria [1 ]
Santoro, Miritello [1 ]
Maria Kedor-Hackmann, Erika Rosa [1 ]
机构：
[1] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Pharm, BR-05508900 Sao Paulo, Brazil
来源：
ANALYTICAL LETTERS | 2008年 / 41卷 / 10期
关键词：
high performance liquid chromatography; pancuronium bromide; validation of analytical method;
D O I：
10.1080/00032710802162095
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Pancuronium bromide is used with general anesthesia in surgery for muscle relaxation and as an aid to intubation. A high performance liquid chromatographic method was fully validated for the quantitative determination of pancuronium bromide in pharmaceutical injectable solutions. The analytical method was performed on an amino column (Luna 150mm4.6mm, 5m). The mobile phase was composed of acetonitrile:water containing 50mmol L-1 of 1-octane sulfonic acid sodium salt (20:80v/v) with a flow rate of 1.0mL min-1 and ultraviolet (UV) detection at 210nm. The proposed analytical method was compared with that described in the British Pharmacopoeia.
引用
收藏
页码：1895 / 1908
页数：14
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