The Fast Skeletal Troponin Activator, CK-1909178 Reduces Muscle Fatigue in a Model of Peripheral Artery Disease in Situ

被引:1
|
作者
Hinken, Aaron [1 ]
Driscoll, Lena [1 ]
Lee, Ken [1 ]
Hartman, Jim J. [1 ]
Marquez, David [1 ]
Hansen, Richard [1 ]
Muci, Alex [1 ]
Morgan, Bradley [1 ]
Malik, Fady [1 ]
Russell, Alan J. [1 ]
机构
[1] Cytokinetics Inc, San Francisco, CA USA
关键词
D O I
10.1016/j.bpj.2009.12.2945
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
引用
收藏
页码:543A / 543A
页数:1
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    Hansen, Richard
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    [J]. BIOPHYSICAL JOURNAL, 2009, 96 (03) : 231A - 231A
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