THE DRUG RELEASE FROM LIPOSOMAL CARRIER WITHIN THE CHITOSAN MATRIX

The release and regulation of growth factors are very important in the tissue regeneration. Optimal and suitable drug carrier systems combined with scaffold are needed to be exploited. In this study, we developed an injectable scaffold incorporated with drug release system for tissue regeneration. Hydrophilic or hydrophobic drugs can be encapsulated into liposomes and then dispersed in the temperature-reversible chitosan-glycerophosphate ( GP) hydrogel. Experimental results show that liposomes provide excellent sustained drug release from chitosan matrix when compared with that of free drugs, especially for hydrophilic drugs. The negative charge of the liposome will complex with the positive charge of the chitosan's protonized amine group that results in controlling the drugs release.