A Randomized Trial of Dual-Acting Bronchodilator AZD8871 for Chronic Obstructive Pulmonary Disease

被引:10
|
作者
Singh, Dave [1 ,2 ]
Fuhr, Rainard [3 ]
Jimenez, Lali [4 ]
Hamren, Ulrika Wahlby [5 ]
Jauhiainen, Alexandra [5 ]
Malice, Marie-Pierre [4 ]
Balaguer, Victor [4 ]
Lei, Alejhandra [4 ]
Aggarwal, Ajay [6 ]
Astbury, Carol [4 ]
Psallidas, Ioannis [5 ]
机构
[1] Med Evaluat Unit, Manchester, Lancs, England
[2] Univ Manchester, Manchester, Lancs, England
[3] PAREXEL Early Phase Clin Unit, Berlin, Germany
[4] AstraZeneca, Barcelona, Spain
[5] AstraZeneca, Gothenburg, Sweden
[6] AstraZeneca, Boston, MA USA
关键词
D O I
10.1164/rccm.201812-2345LE
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
引用
收藏
页码:1282 / 1284
页数:3
相关论文
共 50 条
  • [1] A randomized placebo controlled trial of AZD8871 a novel dual acting bronchodilator in asthmatics
    Jimenez, Lali
    Astbury, Carol
    Seoane, Beatriz
    Villarroel, Cristina
    Pujol, Helena
    Bermejo, Maria-Jesus
    Aggarwal, Ajay
    Albayaty, Muna
    EUROPEAN RESPIRATORY JOURNAL, 2017, 50
  • [2] A randomized placebo and active controlled trial of AZD8871 a novel dual acting bronchodilator in COPD patients
    Singh, Dave
    Astbury, Carol
    Jimenez, Lali
    Seoane, Beatriz
    Villarroel, Cristina
    Balaguer, Victor
    Lei, Alejhandra
    Aggarwal, Ajay
    EUROPEAN RESPIRATORY JOURNAL, 2017, 50
  • [3] A Phase 2a Randomized, Double-Blind, Placebo-Controlled Trial of AZD8871, a Novel Dual-Acting Bronchodilator in COPD Patients
    Psallidas, I.
    Singh, D.
    Astbury, C.
    Jimenez, L.
    Hamren, U. Wahlby
    Seoane, B.
    Malice, M.
    Balaguer, V.
    Lei, A.
    Aggarwal, A.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 197
  • [4] An Ascending, Repeat-Dose Safety and Tolerability Study of AZD8871 a Novel, Dual-Acting Bronchodilator in Healthy Volunteers
    Astbury, C.
    Jimenez, L.
    Seoane, B.
    Villarroel, C.
    Albayaty, M.
    Balaguer, V.
    Lei, A.
    Aggarwal, A.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 197
  • [5] Considerations for new dual-acting bronchodilator treatments for chronic obstructive pulmonary disease
    de Miguel-Diez, Javier
    Jimenez-Garcia, Rodrigo
    EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2014, 23 (04) : 453 - 456
  • [6] Navafenterol (AZD8871) in patients with COPD: a randomized, double-blind, phase I study evaluating safety and pharmacodynamics of single doses of this novel, inhaled, long-acting, dual-pharmacology bronchodilator
    Singh, Dave
    Balaguer, Victor
    Astbury, Carol
    Waehlby-Hamren, Ulrika
    Jimenez, Eulalia
    Seoane, Beatriz
    Villarroel, Cristina
    Lei, Alejhandra
    Aggarwal, Ajay
    Psallidas, Ioannis
    RESPIRATORY RESEARCH, 2020, 21 (Suppl 1)
  • [7] Navafenterol (AZD8871) in patients with COPD: a randomized, double-blind, phase I study evaluating safety and pharmacodynamics of single doses of this novel, inhaled, long-acting, dual-pharmacology bronchodilator
    Dave Singh
    Victor Balaguer
    Carol Astbury
    Ulrika Wählby-Hamrén
    Eulalia Jimenez
    Beatriz Seoane
    Cristina Villarroel
    Alejhandra Lei
    Ajay Aggarwal
    Ioannis Psallidas
    Respiratory Research, 21
  • [8] Long-acting dual bronchodilator therapy (indacaterol/glycopyrronium) versus nebulized short-acting dual bronchodilator (salbutamol/ipratropium) in chronic obstructive pulmonary disease: A double-blind, randomized, placebo-controlled trial
    van Geffen, Wouter H.
    Carpaij, Orestes A.
    Westbroek, Lotte F.
    Seigers, Dianne
    Niemeijer, Alice
    Vonk, Judith M.
    Kerstjens, Huib A. M.
    RESPIRATORY MEDICINE, 2020, 171
  • [9] Dual Bronchodilator Therapy with Umeclidinium/Vilanterol Versus Tiotropium plus Indacaterol in Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial
    Kalberg C.
    O’Dell D.
    Galkin D.
    Newlands A.
    Fahy W.A.
    Drugs in R&D, 2016, 16 (2) : 217 - 227
  • [10] Long-Acting Bronchodilator Therapy for the Treatment of Chronic Obstructive Pulmonary Disease
    Chen, Andrea M.
    Bollmeier, Suzanne G.
    Finnegan, Patrick M.
    ANNALS OF PHARMACOTHERAPY, 2008, 42 (12) : 1832 - 1842