Enhanced expression of IL-27 mRNA in human newborns

被引：13
|
作者：
Krumbiegel, Doreen [1 ]
Anthogalidis-Voss, Christina [1 ]
Markus, Helena [1 ]
Zepp, Fred [1 ]
Meyer, Claudius U. [1 ]
机构：
[1] Johannes Gutenberg Univ Mainz, Childrens Hosp, Dept Pediat Immunol, D-55131 Mainz, Germany
来源：
PEDIATRIC ALLERGY AND IMMUNOLOGY | 2008年 / 19卷 / 06期
关键词：
cord blood; dendritic cells; Epstein-Barr virus-induced gene 3; neonatal; WSX-1;
D O I：
10.1111/j.1399-3038.2007.00685.x
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Interleukin (IL)-27, a heterodimer composed of Epstein-Barr virus-induced gene 3 (EBI3) and p28, is an early product of activated dendritic cells (DC). Binding of IL-27 to the WSX-1 receptor initiates Th1 (Thelper 1) responses in naive T cells. In order to assess the Th1 responses in human neonates with high susceptibility to infectious diseases, expression of EBI3-, p28- and WSX-1-mRNA in response to Toll-like receptor ligands was compared in neonate and adult monocyte-derived (m)DC. Only the combined addition of ligands induced expression of IL-27p28 mRNA. Surprisingly, neonatal mDC produced significantly more IL-27p28 mRNA than that obtained from adults. Furthermore, there was enhanced expression of EBI3 mRNA in cord blood as compared with adult blood. In addition, the secretion of WSX-1 mRNA in neonatal mDC and T cells was also significantly increased. Taken together, these findings indicate that the restricted Th1 responses in human newborns owing to deficient IL-12 production may be compensated for, in part, by enhanced IL-27 secretion.
引用
收藏
页码：513 / 516
页数：4
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