Targeted genotyping for the prediction of celiac disease autoimmunity development in patients with type 1 diabetes and their family members

被引:3
|
作者
Leonard, Maureen M. [1 ,2 ,3 ]
Camhi, Stephanie [1 ,2 ,3 ]
Kenyon, Victoria [1 ,2 ,3 ]
Betensky, Rebecca A. [4 ]
Sturgeon, Craig [1 ,2 ,3 ]
Yan, Shu [1 ,2 ,3 ]
Fasano, Alessio [1 ,2 ,3 ]
机构
[1] Mass Gen Hosp Children, Mucosal Immunol & Biol Res Ctr, Boston, MA 02115 USA
[2] Mass Gen Hosp Children, Ctr Celiac Res & Treatment, Boston, MA 02115 USA
[3] Mass Gen Hosp Children, Dept Pediat Gastroenterol & Nutr, Boston, MA 02114 USA
[4] Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
关键词
Screening; Gluten; Diabetic; Coeliac; Haptoglobin; Human leukocyte antigen; HAPTOGLOBIN GENOTYPE; COMPLICATIONS TRIAL/EPIDEMIOLOGY; GUT PERMEABILITY; TIGHT JUNCTIONS; UNITED-STATES; HUMAN ZONULIN; 52,721 YOUTH; PREVALENCE; MODULATOR; RISK;
D O I
10.4239/wjd.v10.i3.189
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND Patients with type 1 diabetes (T1D) and their first-degree relatives (FDRs) have an increased risk of developing celiac disease (CD) compared to the general population. This is largely explained by the shared association with major histocompatibility class II human leukocyte antigen (HLA) DQ2 and/or DQ8 between the two disease states. AIM To describe the frequency of CD autoimmunity (CDA) and the distribution of HLA and haptoglobin genotypes in patients with T1D and their FDRs. Additionally, we aimed at identifying predictors associated with an increased risk of developing CDA in patients with T1D and their family members. METHODS We obtained clinical information and blood samples from 1027 participants (302 with T1D and 725 FDRs) over a five-year period. Samples were tested for autoantibodies associated with CD, HLA-DQ alleles, and haptoglobin genotype.We fit univariate and multiple logistic regression models for CDA separately for subjects with T1D and for FDRs of subjects with T1D. RESULTS Implementation of a screening program increased the frequency of CDA by 2fold in participants with T1D and 2.8-fold in their FDRs. Multivariate analysis found that, in participants with T1D, having both DR7-DQ2 and DR4-DQ8 was associated with an increased frequency of CDA. In FDRs of T1D patients, reported CD in the family was associated with an increased frequency of CDA during screening. Haptoglobin 2 genotype was not associated with developing CDA in the multivariate analysis. CONCLUSION Patients with T1D and their FDRs have a high frequency of CDA. Carrying both DR7-DQ2 and DR4-DQ8 was associated with development of CDA in patients with T1D.
引用
收藏
页码:189 / 199
页数:11
相关论文
共 50 条
  • [1] Transglutaminase antibodies and celiac disease in children with type 1 diabetes and in their family members
    Parkkola, Anna
    Haerkoenen, Taina
    Ryhaenen, Samppa J.
    Uibo, Raivo
    Ilonen, Jorma
    Knip, Mikael
    [J]. PEDIATRIC DIABETES, 2018, 19 (02) : 305 - 313
  • [2] HLA-DQ Genotyping in Patients with Type 1 Diabetes Mellitus and Celiac Disease
    Agrawal, Neeraj
    Bhandari, Shweta
    Andleeb, Andleeb Zehra
    Singh, Usha
    [J]. HORMONE RESEARCH IN PAEDIATRICS, 2018, 90 : 243 - 243
  • [3] Prevalence of celiac disease in family members of patients with celiac disease
    Mishra, A.
    Verma, A. K.
    Sharma, M.
    Das, P.
    Gupta, S. D.
    Makharia, G. K.
    [J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2011, 26 : 250 - 250
  • [4] The role of autoimmunity at diagnosis of type 1 diabetes in the development of thyroid and celiac disease and microvascular complications
    Glastras, SJ
    Craig, ME
    Verge, CF
    Chan, AK
    Cusumano, JM
    Donaghue, KC
    [J]. DIABETES CARE, 2005, 28 (09) : 2170 - 2175
  • [5] Co-occurrence of Type 1 Diabetes and Celiac Disease Autoimmunity
    Hagopian, William
    Lee, Hye-Seung
    Liu, Edwin
    Rewers, Marian
    She, Jin-Xiong
    Ziegler, Anette-G.
    Lernmark, Ake
    Toppari, Jorma
    Rich, Stephen S.
    Krischer, Jeffrey P.
    Erlich, Henry
    Akolkar, Beena
    Agardh, Daniel
    [J]. PEDIATRICS, 2017, 140 (05)
  • [6] Contrasting the Genetic Background of Type 1 Diabetes and Celiac Disease Autoimmunity
    Gutierrez-Achury, Javier
    Romanos, Jihane
    Bakker, Sjoerd F.
    Kumar, Vinod
    de Haas, Esther C.
    Trynka, Gosia
    Ricano-Ponce, Isis
    Steck, Andrea
    Chen, Wei-Min
    Onengut-Gumuscu, Suna
    Simsek, Suat
    Rewers, Marian
    Mulder, Chris J.
    Liu, Ed
    Rich, Stephen S.
    Wijmenga, Cisca
    [J]. DIABETES CARE, 2015, 38 : S37 - S44
  • [7] The prevalence of celiac disease among family members of celiac disease patients
    Dolinsek, J
    Urlep, D
    Karell, K
    Partanen, J
    Micetic-Turk, D
    [J]. WIENER KLINISCHE WOCHENSCHRIFT, 2004, 116 : 8 - 12
  • [8] Prevalence of Celiac Disease, Undiagnosed Celiac Disease, and Coexisting Autoimmunity in Youth with Type 1 Diabetes: The SEARCH for Diabetes in Youth Study
    Brady, Ryan
    Jensen, Elizabeth T.
    Rigdon, Joseph
    Crimmins, Nancy A.
    Mallon, Daniel
    Dolan, Lawrence M.
    Imperatore, Giuseppina
    Kahkoska, Anna
    Mottl, Amy K.
    Honor, Ann
    Pettitt, David J.
    Merjaneh, Lina
    Dabelea, Dana
    Shah, Amy S.
    [J]. DIABETES, 2021, 70
  • [9] Impact of celiac autoimmunity on children with type 1 diabetes
    Simmons, Jill H.
    Klingensmith, Georgeanna J.
    McFann, Kim
    Rewers, Marian
    Taylor, Jennifer
    Emery, Lisa M.
    Vanyi, Sharon
    Liu, Edwin
    Hoffenberg, Edward J.
    [J]. JOURNAL OF PEDIATRICS, 2007, 150 (05): : 461 - 466
  • [10] Celiac Autoimmunity (CA) and Celiac Disease (CD) in Children with Type 1 Diabetes (T1D)
    Schaub, Rebecca L.
    Escalante, Mirna
    Haymond, Morey
    Redondo, Maria J.
    [J]. DIABETES, 2015, 64 : A18 - A18