More than Meets the Eye: Hidden Structures in the Proteome
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作者:
Wasserman, Hal
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Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USAScripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
Wasserman, Hal
[1
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Saphire, Erica Ollmann
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Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USAScripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
Saphire, Erica Ollmann
[1
,2
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机构:
[1] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
A central dogma of molecular biology is that the sequence of a protein dictates its particular fold and the fold dictates its function. Indeed, the sequence. structure. function hypothesis has been a guiding principle by which scientists approach molecular biology. Every student knows that the genome encodes information for the progression from primary sequence to secondary, tertiary, and ultimately quaternary structure. Yet with a growing number of proteins, a fifth level has been identified: rearrangement of existing structures into distinct forms. Recent observations indicate that replication of Ebola virus depends on this fifth level. We believe other viruses with compact genomes and rapid evolution under selective pressure will be a rich source of examples of polypeptides that rearrange to gain added functions. In this review, we describe mechanisms by which viral, prokaryotic, and eukaryotic polypeptides have adopted alternate structures to control or gain function.
机构:
Ctr Hosp Univ Reims, Hop Robert Debre, Serv Ophtalmol, Reims, FranceCtr Hosp Univ Reims, Hop Robert Debre, Serv Ophtalmol, Reims, France
Dormegnie, Louis-Philippe
Henry, Adrien
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Ctr Hosp Univ Reims, Hop Robert Debre, Serv Ophtalmol, Reims, FranceCtr Hosp Univ Reims, Hop Robert Debre, Serv Ophtalmol, Reims, France
Henry, Adrien
Salmon, Jean-Hugues
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Ctr Hosp Univ Reims, Hop Maison Blanche, Serv Rhumatol, Reims, FranceCtr Hosp Univ Reims, Hop Robert Debre, Serv Ophtalmol, Reims, France
Salmon, Jean-Hugues
N'Guyen, Yohan
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Ctr Hosp Univ Reims, Hop Robert Debre, Serv Med Interne Malad Infect & Immunol Clin, Reims, FranceCtr Hosp Univ Reims, Hop Robert Debre, Serv Ophtalmol, Reims, France
机构:
Prince Charles Hosp, Thorac Med, Brisbane, Qld, Australia
Univ Queensland, Fac Med, UQ Thorac Res Ctr, Brisbane, Qld, AustraliaPrince Charles Hosp, Thorac Med, Brisbane, Qld, Australia
Olive, Gerard N.
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Yang, Ian A.
Marshall, Henry
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Prince Charles Hosp, Thorac Med, Brisbane, Qld, Australia
Univ Queensland, Fac Med, UQ Thorac Res Ctr, Brisbane, Qld, AustraliaPrince Charles Hosp, Thorac Med, Brisbane, Qld, Australia