Difluoromethylenediphosphonate: A convenient, scalable, and high-yielding synthesis

被引：11
|
作者：
Boyle, NA [1 ]
机构：
[1] Biota Inc, Carlsbad, CA 92009 USA
来源：
ORGANIC LETTERS | 2006年 / 8卷 / 02期
关键词：
D O I：
10.1021/ol0522889
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Since the first disclosure of difluoromethylenediphosphonate, 2, almost 40 years ago, interest in this compound has flourished in several research areas. In this paper, we present a convenient, high-yielding (99% overall) method for the preparation of milligram to multigrarn quantities of 2 (as the bis(tributylammonium salt, 2b) in a solid form that is easy to handle.
引用
收藏
页码：187 / 189
页数：3
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