Ammonium-dependent hydrogen peroxide production by mitochondria

被引：19

作者：

Grivennikova, Vera G. ^{[1
]}

Cecchini, Gary ^{[2
,4
]}

Vinogradov, Andrei D. ^{[1
,3
]}

机构：

[1] Moscow MV Lomonosov State Univ, Sch Biol, Dept Biochem, Moscow 119992, Russia

[2] VA Med Ctr, Div Mol Biol, San Francisco, CA 94121 USA

[3] Moscow MV Lomonosov State Univ, Mitoengn Ctr, Moscow 119992, Russia

[4] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94158 USA

来源：

FEBS LETTERS | 2008年 / 582卷 / 18期

关键词：

hydrogen peroxide; mitochondria; complex I; ammonium;

D O I：

10.1016/j.febslet.2008.06.054

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

NADH-supported generation of H2O2 by permeabilized rat heart mitochondria was partially prevented by the specific complex I-directed inhibitor, NADH-OH, and was significantly stimulated by ammonium. Ammonium did not affect H2O2 production by complex I in coupled submitochondrial particles. The soluble mitochondrial matrix protein fraction catalyzed NADH-dependent H2O2 production, which was greatly ( similar to 10fold) stimulated by ammonium. We conclude that complex I is not the major contributor to mitochondrial superoxide ( hydrogen peroxide) generation and that there are specific ammonium-sensitive NADH: oxygen oxidoreductase(s) in the mitochondrial matrix which are responsible for mitochondrial H2O2 production. (c) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：2719 / 2724

页数：6

共 50 条

[1] Molecular identification of the enzyme responsible for the mitochondrial NADH-supported ammonium-dependent hydrogen peroxide production
Kareyeva, Alexandra V.
Grivennikova, Vera G.
Cecchini, Gary
Vinogradov, Andrei D.
FEBS LETTERS, 2011, 585 (02): : 385 - 389
[2] Superoxide and hydrogen peroxide production by Drosophila mitochondria
Miwa, S
St-Pierre, J
Partridge, L
Brand, MD
FREE RADICAL BIOLOGY AND MEDICINE, 2003, 35 (08) : 938 - 948
[3] What are the sources of hydrogen peroxide production by heart mitochondria?
Grivennikova, Vera G.
Kareyeva, Alexandra V.
Vinogradov, Andrei D.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2010, 1797 (6-7): : 939 - 944
[4] What are the sources of hydrogen peroxide production by heart mitochondria?
Vinogradov, Andrei D.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2010, 1797 : 57 - 57
[5] Ammonium-dependent respiratory increase is dependent on the cytochrome pathway in Arabidopsis thaliana shoots
Hachiya, Takushi
Watanabe, Chihiro K.
Boom, Carolina
Tholen, Danny
Takahara, Kentaro
Kawai-Yamada, Maki
Uchimiya, Hirofumi
Uesono, Yukifumi
Terashima, Ichiro
Noguchi, Ko
PLANT CELL AND ENVIRONMENT, 2010, 33 (11): : 1888 - 1897
[6] DETERMINATION OF THE PRODUCTION OF SUPEROXIDE RADICALS AND HYDROGEN-PEROXIDE IN MITOCHONDRIA
BOVERIS, A
METHODS IN ENZYMOLOGY, 1984, 105 : 429 - 435
[7] Excessive Production of Hydrogen Peroxide in Mitochondria Contributes to Atopic Dermatitis
Minzaghi, Deborah
Pavel, Petra
Kremslehner, Christopher
Gruber, Florian
Oberreiter, Sophie
Hagenbuchner, Judith
Del Frari, Barbara
Blunder, Stefan
Gruber, Robert
Dubrac, Sandrine
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2023, 143 (10) : 1906 - 1918.e8
[8] HYDROGEN-PEROXIDE PRODUCTION BY MITOCHONDRIA MAY BE A BIOMARKER OF AGING
SOHAL, RS
MECHANISMS OF AGEING AND DEVELOPMENT, 1991, 60 (02) : 189 - 198
[9] Hydrogen peroxide production by myocardial mitochondria is reduced by exercise training
Starnes, JW
Barnes, BD
Olsen, ME
CIRCULATION RESEARCH, 2005, 97 (02) : E41 - E41
[10] Electrochemical Monitoring of the Early Events of Hydrogen Peroxide Production by Mitochondria
Suraniti, Emmanuel
Ben-Amor, Salem
Landry, Pauline
Rigoulet, Michel
Fontaine, Eric
Bottari, Serge
Devin, Anne
Sojic, Neso
Mano, Nicolas
Arbault, Stphane
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 53 (26) : 6655 - 6658

← 1 2 3 4 5 →