Evolution of Robustness and Cellular Stochasticity of Gene Expression

被引：15
|
作者：
Frank, Steven A. [1 ]
机构：
[1] Univ Calif Irvine, Dept Ecol & Evolutionary Biol, Irvine, CA 92717 USA
来源：
PLOS BIOLOGY | 2013年 / 11卷 / 06期
基金：
美国国家科学基金会;
关键词：
CELLS;
D O I：
10.1371/journal.pbio.1001578
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Gene expression varies widely in cells with the same genotype and environment [1,2]. Predicting the patterns of stochastic cellular fluctuations remains an unsolved challenge. I propose that the degree to which varying cellular components combine to determine robust phenotypes may predict the amount of variability. Microbes provide excellent experimental models to analyze the relations between robust phenotypes and stochastic variability.
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页数：3
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