Solvent-free 1,3-Dipolar Cycloaddition of Azomethine Imines with Terminal Alkynes Promoted by Calcium Fluoride Under the Ball Milling Condition

被引：9
|
作者：
Chen Xianglong [1 ]
Jia Chunman [1 ,2 ]
Cao Li [1 ]
Zhang Dela [1 ]
Liu Shuixiang [2 ]
Zhang Qi [1 ]
机构：
[1] Hainan Univ, Hainan Prov Key Lab Fine Chem, Haikou 570228, Peoples R China
[2] Hainan Univ, Key Study Ctr Minist Educ Trop Resources Utilizat, Haikou 570228, Peoples R China
来源：
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2015年 / 31卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Ball-milling; 1,3-Dipolar cycloaddition; Click chemistry; Solvent-free reaction; (S)-PROLINE-CONTAINING DIPEPTIDES; MECHANOCHEMISTRY; COPPER; CATALYST;
D O I：
10.1007/s40242-015-4480-0
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A convenient and efficient procedure for the synthesis of N, N-bicyclic pyrazolidinone derivatives has been developed via the reaction of azomethine imines with terminal alkynes under the ball milling condition without solvent, which was promoted by calcium fluoride with a catalyst of copper(I) salt. The cyclization reactions exhibited moderate to high yields.
引用
收藏
页码：543 / 548
页数：6
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