Cost-effectiveness analysis of nivolumab compared to pembrolizumab in the treatment of recurrent or metastatic squamous cell carcinoma of the head and neck

Pembrolizumab and nivolumab are anti-PD-1 immunotherapy agents approved for the treatment of metastatic or recurrent head and neck squamous cell carcinoma (HNSCC) with demonstrated benefit as shown by the CheckMate 141 and KEYNOTE-040 clinical trials. Increasing costs of anticancer drugs in particular may influence the choice of treatment. There are limited data and mixed results on the cost-effectiveness of these immunotherapy agents when used in the setting of recurrent or metastatic HNSCC. This study compares the cost-effectiveness of pembrolizumab and nivolumab in this setting. Data published from the CheckMate 141 and KEYNOTE-040 studies were used to generate a model estimating treatment costs and overall survival benefit. Cost of treatment of toxicity-related events were obtained from previous literature and incorporated into calculated costs. Data from both experimental arms and both standard of care arms in the two studies were used for cost estimation in the model. An adjusted standard of care arm was derived from existing data as a common comparator for nivolumab and pembrolizumab. The initial incremental cost-effectiveness ratio (ICER) for nivolumab was $409,000 per quality-adjusted life year (QALY). The initial ICER for pembrolizumab was $1,137,595/QALY. Comparison to adjusted standard of care arm resulted in ICERs of $484,000/QALY and $856,173/QALY, for nivolumab and pembrolizumab, respectively. Nivolumab appears to have a lower cost per QALY and may be more cost-effective than pembrolizumab. Neither drug would be considered a cost-effective treatment option at a threshold of $100,000/QALY for patients in this setting. Outcomes of improved long-term survival have yet to be reported as these agents are relatively new; incorporation of this future data would likely improve the cost-effectiveness of these drugs.