Tiam1 gene expression and its significance in colorectal carcinoma

被引：39

作者：

Liu, Li ^{[1
]}

Wu, De-Hua ^{[2
]}

Ding, Yan-Qing ^{[1
]}

机构：

[1] First Mil Med Univ, Dept Pathol, Guangzhou 510515, Guangdong, Peoples R China

[2] First Mil Med Univ, Nanfang Hosp, Dept Radiat Oncol, Guangzhou 510515, Guangdong, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2005年 / 11卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Colorectal carcinoma; Tiam1; gene; Gene expression; Tumor metastasis;

D O I：

10.3748/wjg.v11.i5.705

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To explore the expression of Tiam1 gene in colorectal carcinoma and its correlation with tumor metastasis. METHODS: Expressions of Tiam1 gene in 8 colorectal carcinoma cell lines were detected by reverse transcriptase-polymerase chain reaction. In vitro invasiveness was determined by means of Matrigel invasion assay. The correlation of Tiam1 expression with the invasive ability was also analyzed. RESULTS: Tiam1 gene was highly expressed in LoVo and SW620, which were established from metastatic colorectal carcinomas in comparison with LS174T, SW480, HCT116, LST, HRT-18 and Hee8693, which were established from primary colorectal carcinomas. In vitro cell invasivion demonstrated that LoVo and SW620 had a higher invasive ability than LS174T, SW480, HCT116, LST, HRT-18 and Hee8693. The expression of Tiam1 gene was highly related to the metastatic potential of colorectal carcinoma cells. CONCLUSION: Tiam1 gene may play an important role in invasion and metastasis of colorectal carcinoma and is a metastasis-related gene. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.

引用

页码：705 / 707

页数：3

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