Cysteine-derived organocatalyst in a highly enantioselective intramolecular Michael reaction

被引：194
|
作者：
Hayashi, Y [1 ]
Gotoh, H [1 ]
Tamura, T [1 ]
Yamaguchi, H [1 ]
Masui, R [1 ]
Shoji, M [1 ]
机构：
[1] Tokyo Univ Sci, Fac Engn, Dept Ind Chem, Shinjuku Ku, Tokyo 1628601, Japan
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2005年 / 127卷 / 46期
关键词：
D O I：
10.1021/ja055740s
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Asymmetric intramolecular Michael reaction catalyzed by an organocatalyst derived from cysteine has been developed for the synthesis of chiral bicyclo[4.3.0]nonene and cis-disubstituted cyclopentane skeletons with a creation of three or two contiguous chiral centers in good yield with high diastereo- and excellent enantioselectivities. Copyright © 2005 American Chemical Society.
引用
收藏
页码：16028 / 16029
页数：2
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