VEGF and MMP-9: biomarkers for canine lymphoma

被引：25

作者：

Aresu, L. ^{[1
]}

Arico, A. ^{[1
]}

Comazzi, S. ^{[2
]}

Gelain, M. E. ^{[2
]}

Riondato, F. ^{[3
]}

Mortarino, M. ^{[2
]}

Morello, E. ^{[3
]}

Stefanello, D. ^{[4
]}

Castagnaro, M. ^{[1
]}

机构：

[1] Univ Padua, Fac Vet Med, Dept Publ Hlth Comparat Pathol & Vet Hyg, I-35020 Legnaro, Italy

[2] Univ Milan, Fac Vet Med, Dept Anim Pathol Publ Hlth & Vet Hyg, Milan, Italy

[3] Univ Torino, Fac Vet Med, Dept Anim Pathol, Grugliasco, TO, Italy

[4] Univ Milan, Fac Vet Med, Dept Vet Sci, Milan, Italy

来源：

VETERINARY AND COMPARATIVE ONCOLOGY | 2014年 / 12卷 / 01期

关键词：

ENDOTHELIAL GROWTH-FACTOR; MATRIX METALLOPROTEINASES; FACTOR-BETA; CELL-GROWTH; EXPRESSION; DOGS; MATRIX-METALLOPROTEINASE-9; ANGIOGENESIS; CORRELATE; SUBTYPES;

D O I：

10.1111/j.1476-5829.2012.00328.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Vascular endothelial growth factor (VEGF) and metalloproteinase (MMP) 2 and 9 are useful biomarkers in human lymphoma. During cancerogenesis, transforming growth factor beta (TGF-β) stimulates VEGF and MMPs production. VEGF and TGF-β plasma levels were tested by ELISA, MMP-2 and MMP-9 by gelatine zymography in 37 dogs with lymphoma, 13 of which were also monitored during chemotherapy. Ten healthy dogs served as control. Lymphoma dogs showed higher act-MMP-9 (P<0.01) and VEGF (P<0.05), and lower TGF-β than controls, and a positive correlation between act-MMP-9 and VEGF (P<0.001). Act-MMP-9 and VEGF were significantly higher in T-cell lymphomas, and in stage V compared with stages III-IV disease, regardless of immunophenotype. VEGF was higher in high-grade compared with low-grade T-cell lymphomas. No correlation was found between cytokines levels at presentation and outcome. During chemotherapy, act-MMP-9 and VEGF decreased in B-cell lymphomas (P<0.01), suggesting a possible predictive role in this group of dogs. © 2012 John Wiley & Sons Ltd.

引用

页码：29 / 36

页数：8

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