5-{[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-Trimethylperhydro-3,12-epoxy-1,2-dioxepino[4,3-i]isochromen-10-yl]oxymethyl}benzene-1,3-diol

被引：2
|
作者：
Gul, Waseem [1 ]
Carvalho, Paulo [2 ]
Galal, Ahmed [3 ]
Avery, Mitchell A. [2 ,3 ,4 ]
El Sohly, Mahmoud A. [1 ,3 ]
机构：
[1] El Sohly Labs Inc, Oxford, MS 38655 USA
[2] Univ Mississippi, Dept Med Chem, University, MS 38677 USA
[3] Univ Mississippi, Sch Pharm, Dept Pharmaceut, Natl Ctr Nat Prod Res, University, MS 38677 USA
[4] Univ Mississippi, Dept Chem & Biochem, University, MS 38677 USA
来源：
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2009年 / 65卷
基金：
美国国家卫生研究院;
关键词：
ARTEMISININ DERIVATIVES;
D O I：
10.1107/S1600536809002050
中图分类号：
O7 [晶体学];
学科分类号：
0702 ; 070205 ; 0703 ; 080501 ;
摘要：
The title compound, C22H30O7, is a fused five-ring system that is of interest for its anticancer and antimalarial activity. The six-membered C-6 and C5O rings display chair conformations. The six- membered C3O3 ring containing the ether and peroxy functionalities has a distorted boat conformation, with a C-O-O-C torsion angle of 42.6 (1)degrees for the peroxy group. The seven-membered C6O ring has a distorted boat-type conformation, while the seven-membered C5O2 ring has a very distorted chair-type conformation. The structure contains intermolecular O-H center dot center dot center dot O and O-H center dot center dot center dot(O,O) bonds that link the molecules into sheets parallel to the (100) planes.
引用
收藏
页码：O358 / U2473
页数：11
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