Glioblastoma cancer stem cells - From concept to clinical application

被引：51
|
作者：
Stopschinski, Barbara E. [1 ]
Beier, Christoph P. [1 ]
Beier, Dagmar [1 ]
机构：
[1] Univ Hosp, Sch Med, Rhein Westfal TH Aachen, Dept Neurol,JARA Brain, D-52074 Aachen, Germany
来源：
CANCER LETTERS | 2013年 / 338卷 / 01期
关键词：
Cancer stern cells; CD133; Glioblastoma; Radioresistance; Chemoresistance; MAGNETIC-RESONANCE-SPECTROSCOPY; HYPOXIA-INDUCIBLE FACTORS; HIGH-GRADE GLIOMA; GENE-EXPRESSION; SELF-RENEWAL; TGF-BETA; RECURRENT GLIOBLASTOMA; ADJUVANT TEMOZOLOMIDE; TUMOR ANGIOGENESIS; PREDICT PROGNOSIS;
D O I：
10.1016/j.canlet.2012.05.033
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Ten years after the first description of cancer stem cells (CSCs) in glioblastoma (GBM), the initial concept of CSC has been challenged and our understanding of cellular heterogeneity within malignant brain tumors became more complex. The increasing knowledge on CSC also influences preclinical research and clinical practice. This review therefore describes current concepts and controversies on CSC in GBM and summarizes the recent progress how the CSC hypothesis is about to translate into preclinical and clinical application. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：32 / 40
页数：9
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