Endocrine Aspects of Post-traumatic Stress Disorder and Implications for Diagnosis and Treatment

被引：147

作者：

Daskalakis, Nikolaos P. ^{[1
,2
,3
,4
]}

Lehrner, Amy ^{[1
,2
,3
,4
]}

Yehuda, Rachel ^{[1
,2
,3
,4
,5
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Psychiat, Traumat Stress Studies Div, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Dept Psychiat, Lab Mol Neuropsychiat, New York, NY 10029 USA

[3] James J Peters Vet Affairs Med Ctr, PTSD Program, Mental Hlth Care Ctr, Bronx, NY 10468 USA

[4] James J Peters Vet Affairs Med Ctr, Lab Clin Neuroendocrinol & Neurochem, Bronx, NY 10468 USA

[5] Icahn Sch Med Mt Sinai, Dept Neurosci, New York, NY 10029 USA

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2013年 / 42卷 / 03期

关键词：

Stress; Sympathetic; Hypothalamic-pituitary-adrenal axis; Cortisol; Post-traumatic stress disorder; GLUCOCORTICOID-RECEPTOR EXPRESSION; COMBAT VETERANS; LOW CORTISOL; MAJOR DEPRESSION; HORMONE-LEVELS; ANIMAL-MODEL; RISK-FACTORS; HPA AXIS; TRAUMA; PTSD;

D O I：

10.1016/j.ecl.2013.05.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Post-traumatic stress disorder (PTSD) is a serious, multisystem disorder with multiple medical comorbidities. This article reviews the current literature on the endocrine aspects of PTSD, specifically hypothalamic-pituitary-adrenal axis alterations indicative of low cortisol and increased glucocorticoid sensitivity, and the proposed mechanisms whereby these alterations increase risk or reflect pathophysiology. Discussion includes novel treatment innovations and directions for future research.

引用

页码：503 / +

页数：12

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