Targeting cadherin-6 (CDH6) with an antibody-drug conjugate for the treatment of ovarian and renal cancer

被引:1
|
作者
Collins, Scott D.
Saxena, Parmita
Li, Xiao Y.
Shim, Yeonju
Ostrom, Lance
Yoder, Nicholas C.
Catcott, Kalli C.
McShea, Molly A.
Sun, Xiuxia
Bilic, Sanela
Tschantz, William R.
Flaherty, Meghan
Mansfield, Keith
Hu, Tiancen
Capka, Vladimir
Kurz, Markus
Rajlic, Ivana Liric
London, Anne Serdakowski
Duc Nguyen
Mosher, Rebecca
Meyer, Matthew J.
Bourret, Aaron
Saeh, Jamal
Cameron, Scott
Lees, Emma
Bialucha, Carl U.
机构
关键词
D O I
10.1158/1538-7445.AM2016-2974
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
2974
引用
收藏
页数:4
相关论文
共 50 条
  • [1] In vivo activity of a novel CDH6 targeting antibody-drug conjugate, including population-scale ovarian PDX clinical trial
    Bialucha, Carl U.
    Collins, Scott D.
    Shim, Yeonju
    Zhang, Xiamei
    Velazquez, Roberto
    Kowa, Colleen
    Bullock, Caroline
    Cai, Hongbo
    Rivera, Stacy M.
    Goldovitz, Julie M.
    Kurth, Esther
    Loo, Alice T.
    Yang, Guizhi
    Green, John
    Ostrom, Lance
    Meyer, Matthew J.
    Mosher, Rebecca
    Gao, Hui
    Williams, Juliet
    Lees, Emma
    [J]. CANCER RESEARCH, 2016, 76
  • [2] A phase 1, first-in-human study of CUSP06, a cadherin-6 (CDH6) -directed antibody-drug conjugate, in patients with platinum-refractory/resistant ovarian cancer and other advanced solid tumors.
    Spira, Alexander I.
    Lee, Elizabeth Katherine
    O'Cearbhaill, Roisin Eilish
    LoRusso, Patricia
    Falchook, Gerald Steven
    Patel, Manish R.
    Richardson, Debra L.
    Lu, Nicole Covino Wei
    Marreddy, Priya
    Farrington, Daphne L.
    Wheler, Jennifer J.
    Slosberg, Eric Daniel
    Subbiah, Vivek
    Meric-Bernstam, Funda
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [3] Cadherin-6 type 2, K- cadherin (CDH6) is regulated by mutant p53 in the fallopian tube but is not expressed in the ovarian surface
    Karthikeyan, Subbulakshmi
    Lantvit, Daniel D.
    Chae, Dam Hee
    Burdette, Joanna E.
    [J]. ONCOTARGET, 2016, 7 (43) : 69871 - 69882
  • [4] Antibody-drug conjugate for ovarian cancer
    Collingridge, David
    [J]. LANCET ONCOLOGY, 2020, 21 (07): : 886 - 886
  • [5] Raludotatug Deruxtecan, a CDH6-Targeting Antibody-Drug Conjugate with a DNA Topoisomerase I Inhibitor DXd, Is Efficacious in Human Ovarian and Kidney Cancer Models
    Suzuki, Hirokazu
    Nagase, Shotaro
    Saito, Chiemi
    Takatsuka, Atsuko
    Nagata, Motoko
    Honda, Kokichi
    Kaneda, Yuki
    Nishiya, Yumi
    Honda, Tomoyo
    Ishizaka, Tomomichi
    Nakamura, Kensuke
    Nakada, Takashi
    Abe, Yuki
    Agatsuma, Toshinori
    [J]. MOLECULAR CANCER THERAPEUTICS, 2024, 23 (03) : 257 - 271
  • [6] Development of an antibody-drug conjugate targeting TIM-1 for the treatment of ovarian and renal cell carcinoma
    Thomas, Lawrence J.
    Vitale, Laura
    O'Neill, Thomas
    Dolnick, Ree
    Wallace, Paul K.
    Minderman, Hans
    Gergel, Lauren E.
    Forsberg, Eric M.
    Boyer, James M.
    Storey, James R.
    Hammond, Russell A.
    Widger, Jennifer
    Sundarapandiyan, Karuna
    Crocker, Andrea
    Marsh, Henry C.
    Keler, Tibor
    [J]. CANCER RESEARCH, 2014, 74 (19)
  • [7] Construction and Characterization of Cadherin 6 (CDH6)-Targeting Chimeric Antigen Receptor (CAR) Modified T Cells
    Pang, Li
    Ren, Fang
    Xu, Xiaoxuan
    Fu, Lingyang
    Wang, Tifang
    Guo, Zhiqiang
    [J]. JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY, 2022, 41 (01) : 55 - 71
  • [8] Antibody-drug conjugate targeting tissue factor for pancreatic cancer treatment
    Tsumura, Ryo
    Anzai, Takahiro
    Manabe, Shino
    Takashima, Hiroki
    Koga, Yoshikatsu
    Yasunaga, Masahiro
    Matsumura, Yasuhiro
    [J]. CANCER SCIENCE, 2021, 112 : 725 - 725
  • [9] Development of an antibody-drug conjugate panel targeting high grade serous ovarian cancer
    Fu, Ruisi
    Lou, Hantao
    Wang, Ning
    Yan, Dongnan
    Tresserras-Segura, Clara
    Lu, Haonan
    Aboagye, Eric
    [J]. CANCER RESEARCH, 2023, 83 (07)
  • [10] Antibody-drug conjugates for the treatment of ovarian cancer
    Calo, Corinne A.
    O'Malley, David M.
    [J]. EXPERT OPINION ON BIOLOGICAL THERAPY, 2021, 21 (07) : 875 - 887