The relationship between regional and inter-regional functional connectivity deficits in schizophrenia

被引:85
|
作者
Zalesky, Andrew [1 ,2 ]
Fornito, Alex [1 ,2 ,3 ]
Egan, Gary F. [4 ,5 ]
Pantelis, Christos [1 ,2 ]
Bullmore, Edward T. [3 ]
机构
[1] Univ Melbourne, Melbourne Neuropsychiat Ctr, Melbourne, Vic, Australia
[2] Melbourne Hlth, Melbourne, Vic, Australia
[3] Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge, England
[4] Univ Melbourne, Florey Neurosci Inst, Melbourne, Vic, Australia
[5] Univ Melbourne, Ctr Neurosci, Melbourne, Vic, Australia
基金
澳大利亚研究理事会; 英国医学研究理事会;
关键词
network mapping; functioncal connectivity mapping; schizophrenia; WHITE-MATTER ABNORMALITIES; HUMAN BRAIN; SMALL-WORLD; DEFAULT NETWORK; CORTEX; ORGANIZATION; FLUCTUATIONS; 1ST-EPISODE; HOMOGENEITY; ANATOMY;
D O I
10.1002/hbm.21379
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
While schizophrenia is frequently characterized as a disorder of disturbed functional connectivity, the causes and pathophysiological origins of such disturbances remain unclear. The aim of this study was to better elucidate the mechanistic causes of abnormal functional connectivity in schizophrenia, measured as the extent of temporal correlation between endogenous fluctuations recorded at anatomically discrete brain regions during resting-state functional MRI. An approach was developed to perform whole-brain connectivity mapping at the resolution of individual pairs of voxels, without the need for arbitrary parcellation of the cerebrum. Between-group connectivity reductions in 12 people diagnosed with schizophrenia and 15 age-, IQ-, and gender-matched healthy volunteers were localized to a distributed network including frontoparietal and occipitoparietal connections. The gray-matter regions comprising this disturbed network showed evidence of local reductions in both intra-regional homogeneity (29%33% reduction) and signal power (40%60% reduction). The extent to which inter-regional correlation was reduced between a pair of gray matter regions was found to be strongly correlated with the extent of local decoherence evident within the gray matter regions per se. This suggests measurement of aberrant functional connectivity in schizophrenia is both a measurement of altered coupling between regions as well as a measurement of local decoherence within regions. Hum Brain Mapp, 2012. (c) 2011 Wiley Periodicals, Inc.
引用
收藏
页码:2535 / 2549
页数:15
相关论文
共 50 条
  • [1] Altered regional activity and inter-regional functional connectivity in psychogenic non-epileptic seizures
    Li, Rong
    Li, Yibo
    An, Dongmei
    Gong, Qiyong
    Zhou, Dong
    Chen, Huafu
    SCIENTIFIC REPORTS, 2015, 5
  • [2] Functional Connectivity of EEG Regional Delta and Inter-Regional Gamma Activity Correlates with Memory Recall
    Hanouneh, Samer
    Amin, Hafeez Ullah
    Saad, Naufal M.
    Malik, Aamir Saeed
    PROCEEDINGS 5TH IEEE INTERNATIONAL CONFERENCE ON CONTROL SYSTEM, COMPUTING AND ENGINEERING (ICCSCE 2015), 2015, : 504 - 507
  • [3] Altered regional activity and inter-regional functional connectivity in psychogenic non-epileptic seizures
    Rong Li
    Yibo Li
    Dongmei An
    Qiyong Gong
    Dong Zhou
    Huafu Chen
    Scientific Reports, 5
  • [4] The evaluation of the relationship of inter-regional economy and the development strategy of regional economy
    Li, L
    Ye, WZ
    Shen, WL
    PROCEEDINGS OF THE 2001 INTERNATIONAL CONFERENCE ON MANAGEMENT SCIENCE AND ENGINEERING, VOLS I AND II, 2001, : 1243 - 1247
  • [5] Identifying good practices for detecting inter-regional linear functional connectivity from EEG
    Pellegrini, Franziska
    Delorme, Arnaud
    Nikulin, Vadim
    Haufe, Stefan
    NEUROIMAGE, 2023, 277
  • [6] Inter-regional insurance
    Lockwood, B
    JOURNAL OF PUBLIC ECONOMICS, 1999, 72 (01) : 1 - 37
  • [7] PAKISTAN-INDIA TRADE: ROUTE TO INTRA-REGIONAL AND INTER-REGIONAL CONNECTIVITY
    Khan, Rashid Ahmad
    IPRI JOURNAL, 2008, 8 (02): : 19 - 32
  • [8] Decoupling of regional neural activity and inter-regional functional connectivity in Alzheimer’s disease: a simultaneous PET/MR study
    Somayeh Maleki Balajoo
    Farzaneh Rahmani
    Reza Khosrowabadi
    Chun Meng
    Simon B. Eickhoff
    Timo Grimmer
    Mojtaba Zarei
    Alexander Drzezga
    Christian Sorg
    Masoud Tahmasian
    European Journal of Nuclear Medicine and Molecular Imaging, 2022, 49 : 3173 - 3185
  • [9] Decoupling of regional neural activity and inter-regional functional connectivity in Alzheimer's disease: a simultaneous PET/MR study
    Balajoo, Somayeh Maleki
    Rahmani, Farzaneh
    Khosrowabadi, Reza
    Meng, Chun
    Eickhoff, Simon B.
    Grimmer, Timo
    Zarei, Mojtaba
    Drzezga, Alexander
    Sorg, Christian
    Tahmasian, Masoud
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2022, 49 (09) : 3173 - 3185
  • [10] Three-way multidimensional scaling of functional MRI data shows increased heterogeneity of inter-regional connectivity in patients with schizophrenia
    Welchew, D
    Honey, G
    Sharma, T
    Robbins, T
    Bullmore, ET
    NEUROIMAGE, 2001, 13 (06) : S281 - S281