A current review of dose-escalated radiotherapy in locally advanced non-small cell lung cancer

被引：38
|
作者：
Ma, Li [1 ,2 ,3 ]
Men, Yu [3 ,4 ]
Feng, Lingling [1 ,2 ,3 ]
Kang, Jingjing [3 ,5 ]
Sun, Xin [3 ,5 ]
Yuan, Meng [3 ,5 ]
Jiang, Wei [1 ,2 ,3 ]
Hui, Zhouguang [3 ,4 ,5 ]
机构：
[1] Chinese Acad Med Sci, Canc Hosp, Natl Canc Ctr, Dept Radiat Oncol, Panjiayuan Nanli 17, Shenzhen 518116, Peoples R China
[2] Chinese Acad Med Sci, Shenzhen Hosp, Shenzhen 518116, Peoples R China
[3] Peking Union Med Coll, Panjiayuan Nanli 17, Shenzhen 518116, Peoples R China
[4] Chinese Acad Med Sci, Canc Hosp, Natl Canc Ctr, Dept VIP Med Serv, Panjiayuan Nanli 17, Beijing 100021, Peoples R China
[5] Chinese Acad Med Sci, Canc Hosp, Natl Canc Ctr, Dept Radiat Oncol, Beijing 100021, Peoples R China
来源：
RADIOLOGY AND ONCOLOGY | 2019年 / 53卷 / 01期
关键词：
non-small cell lung cancer; dose escalation; hyperfractionation; hypofractionation; adaptive radiotherapy; proton radiotherapy; carbon ion radiotherapy; PHASE-III TRIAL; BODY RADIATION-THERAPY; CONCURRENT CHEMORADIATION; ACCELERATED RADIOTHERAPY; SEQUENTIAL CHEMORADIOTHERAPY; FRACTIONATED RADIOTHERAPY; STAGE-I; BOOST; CHEMOTHERAPY; CARCINOMA;
D O I：
10.2478/raon-2019-0006
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background. The mainstay therapy for locally advanced non-small cell lung cancer is concurrent chemoradiotherapy. Loco-regional recurrence constitutes the predominant failure patterns. Previous studies confirmed the relationship between increased biological equivalent doses and improved overall survival. However, the large randomized phase III study, RTOG 0617, failed to demonstrate the benefit of dose-escalation to 74 Gy compared with 60 Gy by simply increasing fraction numbers. Conclusions. Though effective dose-escalation methods have been explored, including altered fractionation, adapting individualized increments for different patients, and adopting new technologies and new equipment such as new radiation therapy, no consensus has been achieved yet.
引用
收藏
页码：6 / 14
页数：9
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