A Case of Ambiguous External Genitalia in a Thoroughbred Male Horse with the 63,XO/64,XY Mosaic Karyotype

被引：3

作者：

Sato, Fumio ^{[1
,4
]}

Hirota, Keiichi ^{[2
]}

Tozaki, Teruaki ^{[2
]}

Ito, Katsumi ^{[3
]}

Dhakal, Pramod ^{[4
]}

Taya, Kazuyoshi ^{[5
,6
]}

Endo, Yoshiro ^{[1
]}

Murase, Harutaka ^{[1
]}

Nambo, Yasuo ^{[1
,4
]}

机构：

[1] JRA, Hidaka Training & Res Ctr, Urakawa, Hokkaido 0570171, Japan

[2] Lab Racing Chem, Dept Mol Genet, Utsunomiya, Tochigi 3200851, Japan

[3] Hidaka Horse Breeders Assoc, Urakawa, Hokkaido 0593454, Japan

[4] Gifu Univ, United Grad Sch Vet Sci, Dept Vet Clin Sci, Gifu 5011193, Japan

[5] Tokyo Univ Agr & Technol, Fac Agr, Dept Vet Med, Vet Physiol Lab, Fuchu, Tokyo 1838509, Japan

[6] Gifu Univ, United Grad Sch Vet Sci, Dept Vet Basic Sci, Gifu 5011193, Japan

来源：

JOURNAL OF VETERINARY MEDICAL SCIENCE | 2012年 / 74卷 / 10期

关键词：

ambiguous genitalia; horse; mosaic karyotype; SEX-CHROMOSOME ABERRATIONS; 45; X/46; XY MOSAICISM; X-CHROMOSOME; SRY; MARES; INFERTILITY; INHIBIN;

D O I：

10.1292/jvms.11-0473

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

A Thoroughbred colt with ambiguous external genitalia was presented for clinical and histological examinations. The colt had a short penis that faced backward between his hind limbs. The measurements of luteinizing hormone, follicle stimulating hormone, testosterone and ir-inhibin showed a tendency to increase gradually from April. Both the sex-determining region of the Y chromosome and amelogenin gene fragments were detected by the PCR method. A cytogenetic analysis revealed the 63,XO/64,XY mosaic karyotype (ratio 83:17). In autopsy, immature symmetrical subcutaneous testes were found in the inguinal regions. The testes and other accessory sex organs were histologically normal. These results add to our knowledge of chromosomal abnormality and information concerning disorders of sex development in the horse.

引用

页码：1327 / 1331

页数：5

共 10 条

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