Mechanisms Underlying the Effects of Salicylic Acid and Its Salts on Helix Neurons

被引：0
|
作者：
Cheretayev, I. V. [1 ]
Korenyuk, I. I. [1 ]
Khusainov, D. R. [1 ]
Katyushina, O. V. [1 ]
Gamma, T. V. [1 ]
Kolotilova, O. I. [1 ]
机构：
[1] Vernadskii Tavricheskii Natl Univ, Simferopol, Ukraine
来源：
NEUROPHYSIOLOGY | 2012年 / 44卷 / 02期
关键词：
molluscan neurons; salicylic acid; salicylates;
D O I：
10.1007/s11062-012-9282-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
In experiments on Helix neurons, we found that calcium is not involved in the neurotropic effects of salicylic acid and cobalt and zinc salicylates. This conclusion is based on the fact that the addition of BaCl2 to the applied solutions of salicylates did not change the effects of the latter. Extracellular application of adenosine triphosphate (ATP) significantly modified the effects of salicylic acid and its salts. We believe that the inhibitory effect of salicylic acid on Helix neurons depends on the ability of salicylic acid to suppress ATP synthesis, while the activating effect of cobalt and zinc salicylates on neurons is related to the opposite effects of these salts on ATP synthesis.
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页码：153 / 156
页数：4
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