Health-related quality of life in type 1 diabetes without or with symptoms of long-term complications

被引:62
|
作者
Hahl, J
Hämäläinen, H
Sintonen, H
Simell, T
Arinen, S
Simell, O
机构
[1] Turku Sch Econ & Business Adm, Dept Econ, Turku, Finland
[2] Social Insurance Adm, Ctr Res & Dev, Turku, Finland
[3] Univ Helsinki, Dept Publ Hlth, Helsinki, Finland
[4] Univ Turku, Dept Pediat, Turku, Finland
[5] Natl Publ Hlth Inst, Helsinki, Finland
关键词
Health-Related Quality of Life; multi-attribute; symptom impact; type; 1; diabetes; utility;
D O I
10.1023/A:1015684100227
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Objective: To measure subjective health-related quality of life (HRQoL) of patients with type 1 diabetes and describe the influence of symptoms of diabetes-related long-term complications on HRQoL. Methods: The 15-D health-related quality of life measure (15D) was used to measure HRQoL of a representative sample of Finnish insulin-treated patients expected to have type 1 diabetes. Background data were gathered with a separate questionnaire. A tobit (censored regression) model was constructed to estimate the effects of symptoms of complications on HRQoL and to separate these effects from those of other health problems and aging. Results: The 15D scores declined markedly with increasing age, and the prevalence of symptoms of long-term complications increased. The tobit regression model showed that these symptoms have a significant negative influence on HRQoL. The model explained over 50% of the variation in the 15D scores. Conclusions: High prevalence of symptoms of long-term complications combined with their significant negative influence on HRQoL causes substantial losses in terms of quality of life and utility from both individual and societal perspectives. Thus, the importance of secondary prevention, i.e., prevention of complications by better metabolic control, and also the so-far theoretic possibility to prevent type 1 diabetes itself is emphasized.
引用
收藏
页码:427 / 436
页数:10
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