Objective: To measure subjective health-related quality of life (HRQoL) of patients with type 1 diabetes and describe the influence of symptoms of diabetes-related long-term complications on HRQoL. Methods: The 15-D health-related quality of life measure (15D) was used to measure HRQoL of a representative sample of Finnish insulin-treated patients expected to have type 1 diabetes. Background data were gathered with a separate questionnaire. A tobit (censored regression) model was constructed to estimate the effects of symptoms of complications on HRQoL and to separate these effects from those of other health problems and aging. Results: The 15D scores declined markedly with increasing age, and the prevalence of symptoms of long-term complications increased. The tobit regression model showed that these symptoms have a significant negative influence on HRQoL. The model explained over 50% of the variation in the 15D scores. Conclusions: High prevalence of symptoms of long-term complications combined with their significant negative influence on HRQoL causes substantial losses in terms of quality of life and utility from both individual and societal perspectives. Thus, the importance of secondary prevention, i.e., prevention of complications by better metabolic control, and also the so-far theoretic possibility to prevent type 1 diabetes itself is emphasized.
机构:
Hosp Dist Helsinki & Uusimaa, Dept Psychiat, Helsinki, Finland
City Helsinki, Dept Psychiat, Ctr Hlth, Helsinki, Finland
Univ Helsinki, Dept Psychiat, Helsinki, Finland
Aurora Hosp, Nordenskioldinkatu 20, Helsinki 00250, FinlandHosp Dist Helsinki & Uusimaa, Dept Psychiat, Helsinki, Finland
Pohjolainen, Veera
Koponen, Salla
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Hosp Dist Helsinki & Uusimaa, Dept Psychiat, Helsinki, Finland
Univ Helsinki, Dept Psychiat, Helsinki, FinlandHosp Dist Helsinki & Uusimaa, Dept Psychiat, Helsinki, Finland
Koponen, Salla
Rasanen, Pirjo
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机构:
Hosp Dist Helsinki & Uusimaa, External Evaluat Unit, Helsinki, FinlandHosp Dist Helsinki & Uusimaa, Dept Psychiat, Helsinki, Finland
Rasanen, Pirjo
Roine, Risto P.
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机构:
Hosp Dist Helsinki & Uusimaa, External Evaluat Unit, Helsinki, Finland
Univ Eastern Finland, Kuopio, FinlandHosp Dist Helsinki & Uusimaa, Dept Psychiat, Helsinki, Finland
Roine, Risto P.
Sintonen, Harri
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机构:
Univ Helsinki, Dept Publ Hlth, Helsinki, FinlandHosp Dist Helsinki & Uusimaa, Dept Psychiat, Helsinki, Finland
Sintonen, Harri
Karlsson, Hasse
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机构:
Univ Turku, Dept Psychiat, Turku, Finland
Hosp Dist Southwest Finland, Turku, FinlandHosp Dist Helsinki & Uusimaa, Dept Psychiat, Helsinki, Finland