Aeruginosins from a Microcystis sp Bloom Material Collected in Varanasi, India

被引：10
|
作者：
Elkobi-Peer, Shira [1 ,2 ]
Singh, Rahul Kunwar [3 ]
Mohapatra, Tribhuban Mohan [3 ]
Tiwari, Shree Prakash [4 ]
Carmeli, Shmuel [1 ,2 ]
机构：
[1] Tel Aviv Univ, Raymond & Beverly Sackler Sch Chem, IL-69978 Tel Aviv, Israel
[2] Tel Aviv Univ, Fac Exact Sci, IL-69978 Tel Aviv, Israel
[3] Banaras Hindu Univ, Inst Med Sci, Dept Microbiol, Varanasi 221005, Uttar Pradesh, India
[4] VBS Purvanchal Univ, Dept Microbiol, Jaunpur 222001, India
来源：
JOURNAL OF NATURAL PRODUCTS | 2013年 / 76卷 / 06期
基金：
以色列科学基金会;
关键词：
PROTEASE INHIBITORS; AQUATIC ORGANISMS; SERINE PROTEASES; LR; IDENTIFICATION; ISRAEL;
D O I：
10.1021/np4001152
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two novel biologically active short peptides, aeruginosins IN608 and IN652, were isolated from the cyanobacterium Microcystis sp. strain BHU006, which was collected from Durgakund water reservoir in Varanasi, India. Aeruginosins IN608 and IN652 are linear modified peptides containing four building blocks, one of which is the arogenate-derived modified amino acid 2-carboxy-6-hydroxyoctahydroindole. Aeruginosin IN608 and aeruginosin IN652 inhibit the activity of the proteolytic enzyme trypsin with IC50's of 4.3 and 4.1 mu M, respectively.
引用
收藏
页码：1187 / 1190
页数：4
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