Strategies for tackling Taenia solium taeniosis/cysticercosis: A systematic review and comparison of transmission models, including an assessment of the wider Taeniidae family transmission models

Background The cestode Taenia solium causes the neglected (zoonotic) tropical disease cysticercosis, a leading cause of preventable epilepsy in endemic low and middle-income countries. Transmission models can inform current scaling-up of control efforts by helping to identify, validate and optimise control and elimination strategies as proposed by the World Health Organization (WHO). Methodology/Principal findings A systematic literature search was conducted using the PRISMA approach to identify and compare existing T. solium transmission models, and related Taeniidae infection transmission models. In total, 28 modelling papers were identified, of which four modelled T. solium exclusively. Different modelling approaches for T. solium included deterministic, Reed-Frost, individual-based, decision-tree, and conceptual frameworks. Simulated interventions across models agreed on the importance of coverage for impactful effectiveness to be achieved. Other Taeniidae infection transmission models comprised force-of-infection (FoI), population-based (mainly Echinococcus granulosus) and individual-based (mainly E. multilocularis) modelling approaches. Spatial structure has also been incorporated (E. multilocularis and Taenia ovis) in recognition of spatial aggregation of parasite eggs in the environment and movement of wild animal host populations. Conclusions/Significance Gaps identified from examining the wider Taeniidae family models highlighted the potential role of FoI modelling to inform model parameterisation, as well as the need for spatial modelling and suitable structuring of interventions as key areas for future T. solium model development. We conclude that working with field partners to address data gaps and conducting cross-model validation with baseline and longitudinal data will be critical to building consensus-led and epidemiological setting-appropriate intervention strategies to help fulfil the WHO targets. Author summary Taenia solium infection in humans (taeniosis and neurocysticercosis) and pigs (cysticercosis) presents a significant global public health and economic challenge. The World Health Organization has called for validated strategies and wider consensus on which strategies are suitable for different epidemiological settings to support successful T. solium control and elimination efforts. Transmission models can be used to inform these strategies. Therefore, a modelling review was undertaken to assess the current state and gaps relating to T. solium epidemiological modelling. The literature surrounding models for other Taeniidae family infections was also considered, identifying approaches to aid further development of existing T. solium models. A variety of different modelling approaches have been used for T. solium including differences in structural and parametric assumptions associated with T. solium transmission biology. Despite these differences, all models agreed on the importance of coverage on intervention effectiveness. Other Taeniidae family models highlighted the need for incorporating spatial structure when necessary to capture aggregation of transmission stages in the environment and movement of animal hosts.