Polyunsaturated fatty acids (PUFA) regulate neurotransmitter contents in rat brain

被引：0
|
作者：
Varghese, S
Shameena, B
Lakshmy, PS
Biju, MP
Shankar, PNE
Paulose, CS
Oommen, OV [1 ]
机构：
[1] Univ Kerala, Dept Zool, Thiruvananthapuram 695581, Kerala, India
[2] Cochin Univ Sci & Technol, Dept Biotechnol, Cochin 682022, Kerala, India
来源：
INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS | 2001年 / 38卷 / 05期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effects of feeding of 6-propylthiouracil (6-PTU) and polyunsaturated fatty acids (PUFA) independently and in combination and administration (ip) of a single dose of triiodothyronine (T-3) (2.5 mug/100g body wt) along with feeding of 6-PTU and PUFA were studied in rat brain. Dopamine (DA), 5-hydroxytryptophan (5-HTP), serotonin (5-HT), 5-hydroxy indole acetic acid (5-HIAA), norepinephrine (NE) and epinephrine (EPI) contents were assayed in the hypothalamus and cerebral cortex regions, It was found that 6-PTU feeding resulted in decrease in dopamine, 5-HT, 5-HTP and 5-HIAA in both regions. In animals fed with PUFA followed by administration of T-3, the DA level was found normal.
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页码：327 / 330
页数：4
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