Synthesis of the trifluoromethylated retinoial aromatic amide - 4-[1-(5,6,7,8-tetrahydro-3-trifluoromethyl-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic acid

被引：8
|
作者：
Qing, FL [1 ]
Fan, JF [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Organofluorine Chem, Shanghai 200032, Peoples R China
来源：
JOURNAL OF FLUORINE CHEMISTRY | 1999年 / 96卷 / 02期
基金：
中国国家自然科学基金;
关键词：
retinoids; trifluoromethylation;
D O I：
10.1016/S0022-1139(99)00070-6
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A new methodology was developed for the preparation of an o-trifluoromethylated arylamine. The condensation of 2-amino-3-trifluoromethyl-5,6,7,8-tetrahydro-5,5,8,8-tetramethylnaphthalene and terephthalic acid monomethyl ester chloride gave the trifluoromethylated retinoial aromatic amide. The key step in the synthesis is the introduction of the aryl trifluoromethyl group. (C) 1999 Elsevier Science S.A. All rights reserved.
引用
收藏
页码：159 / 161
页数：3
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