Association between a polymorphism in the promoter of a glutamate receptor subunit gene (GRIN2A) and alcoholism

被引：25
|
作者：
Domart, Marie-Charlotte [1 ]
Benyamina, Amine [2 ,3 ]
Lemoine, Antoinette [1 ]
Bourgain, Catherine [3 ]
Blecha, Lisa [2 ,3 ]
Debuire, Brigitte [1 ]
Reynaud, Michel [2 ,3 ]
Saffroy, Raphael [1 ]
机构：
[1] Univ Paris 11, Hop Paul Brousse, AP HP, INSERM,Lab Biochim & Biol Mol,IFR89,U1004, Villejuif, France
[2] Hop Paul Brousse, AP HP, Serv Addictol, F-94800 Villejuif, France
[3] INSERM, U669, Villejuif, France
来源：
ADDICTION BIOLOGY | 2012年 / 17卷 / 04期
关键词：
Addiction; alcohol-dependence; glutamate; GRIN2A; NMDA; (GT)n repeat; SCHIZOPHRENIA; DEPENDENCE; BEHAVIOR; MTHFR;
D O I：
10.1111/j.1369-1600.2011.00321.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A variable (GT)n repeat in the 5'-regulatory region of N-methyl-D-aspartate GRIN2A subtype has recently been identified and associated with psychiatric disorders. In this study, we examined the association of this polymorphism with alcohol dependence. Subjectcontrol analysis included 206 alcohol-dependent and 168 control subjects. Average observed repeat numbers and genotype distributions were significantly different (P-value = 0.001) in alcohol-dependent subjects versus control subjects. Short alleles were significantly less frequent among alcohol-dependent subjects (odds ratio = 0.58, P-value = 7 x 10(-4)). These results could be replicated in an independent sample of 116 alcohol-dependent subjects. For the first time, a significant association was identified between this polymorphism and alcoholism.
引用
收藏
页码：783 / 785
页数：3
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