Development of chiral stationary phases for high-performance liquid chromatographic separation

被引：86
|
作者：
Tang, Mengling [1 ]
Zhang, Jing [1 ]
Zhuang, Shulin [1 ]
Liu, Weiping [1 ]
机构：
[1] Zhejiang Univ, Coll Environm & Resource Sci, MOE Key Lab Environm Remediat & Ecosyst Hlth, Hangzhou 310058, Zhejiang, Peoples R China
来源：
TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2012年 / 39卷
关键词：
Biochemical; Chiral stationary phase (CSP); Chromatography; Computational chemistry; Enantioseparation; High-performance liquid chromatography (HPLC); Preparation; Recognition; Rational design; Resolution; ENANTIOMERIC SEPARATION; OPTICAL RESOLUTION; POLYSACCHARIDE DERIVATIVES; CAPILLARY-ELECTROPHORESIS; AFFINITY-CHROMATOGRAPHY; MOLECULAR DESIGN; LIGAND-EXCHANGE; ALBUMIN-AGAROSE; SILICA; ENANTIOSEPARATION;
D O I：
10.1016/j.trac.2012.07.006
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Chromatography technology based on chiral stationary phases (CSPs) for enantioseparation is widely used for resolution and preparation of biochemicals (e.g., drugs, foods, fragrances and pollutants). In this review, we focus on the development of CSPs for high-performance liquid chromatography (HPLC), including the recognition mechanism, applications and limitations of classical CSPs, newly discovered types of CSP, and also the methods for the rational design of future CSPs on the basis of computational chemistry. Crown Copyright (c) 2012 Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：180 / 194
页数：15
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