BODIPY dyes in photodynamic therapy

被引：1738

作者：

Kamkaew, Anyanee ^{[1
]}

Lim, Siang Hui ^{[2
,3
]}

Lee, Hong Boon ^{[2
]}

Kiew, Lik Voon ^{[4
]}

Chung, Lip Yong ^{[3
]}

Burgess, Kevin ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Chem, College Stn, TX 77841 USA

[2] Subang Jaya Med Ctr, Canc Res Initiat Fdn CARIF, Subang Jaya 47500, Selangor, Malaysia

[3] Univ Malaya, Fac Med, Dept Pharm, Kuala Lumpur 50603, Malaysia

[4] Univ Malaya, Fac Med, Dept Pharmacol, Kuala Lumpur 50603, Malaysia

来源：

CHEMICAL SOCIETY REVIEWS | 2013年 / 42卷 / 01期

基金：

美国国家卫生研究院;

关键词：

SINGLET OXYGEN GENERATION; TUNABLE FLUORESCENT DYES; IN-VITRO; PROTOPORPHYRIN-IX; PHOTOSENSITIZING PROPERTIES; EFFICIENT PHOTOSENSITIZERS; PHOTOPHYSICAL PROPERTIES; BASIC PRINCIPLES; EXCITED-STATES; DERIVATIVES;

D O I：

10.1039/c2cs35216h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

BODIPY dyes tend to be highly fluorescent, but their emissions can be attenuated by adding substituents with appropriate oxidation potentials. Substituents like these have electrons to feed into photoexcited BODIPYs, quenching their fluorescence, thereby generating relatively long-lived triplet states. Singlet oxygen is formed when these triplet states interact with O-3(2). In tissues, this causes cell damage in regions that are illuminated, and this is the basis of photodynamic therapy (PDT). The PDT agents that are currently approved for clinical use do not feature BODIPYs, but there are many reasons to believe that this situation will change. This review summarizes the attributes of BODIPY dyes for PDT, and in some related areas.

引用

页码：77 / 88

页数：12

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