Targeting strategies for drug delivery to the kidney: From renal glomeruli to tubules

被引：71

作者：

Liu, Chun-Ping ^{[1
,2
]}

Hu, You ^{[1
,2
]}

Lin, Ju-Chun ^{[1
,2
]}

Fu, Hua-Lin ^{[1
,2
]}

Lim, Lee Yong ^{[3
]}

Yuan, Zhi-Xiang ^{[1
,2
]}

机构：

[1] Sichuan Agr Univ, Dept Pharm, Coll Vet Med, Chengdu 611130, Sichuan, Peoples R China

[2] Key Lab Anim Dis & Human Hlth Sichuan Prov, Chengdu, Sichuan, Peoples R China

[3] Univ Western Australia, Sch Allied Hlth, Ctr Optimizat Med, Pharm, Crawley 6009, Australia

来源：

MEDICINAL RESEARCH REVIEWS | 2019年 / 39卷 / 02期

基金：

中国博士后科学基金;

关键词：

drug targeting; kidney; mesangial cells; podocytes; renal tubules; RECEPTOR-MEDIATED ENDOCYTOSIS; MOLECULAR-WEIGHT CHITOSAN; MESANGIAL CELLS; TGF-BETA; IN-VIVO; PROTECTS PODOCYTES; LYSOZYME CONJUGATE; QUANTUM DOTS; NANOPARTICLES; DISEASE;

D O I：

10.1002/med.21532

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Kidney diseases have become a global public health problem. The application of kidney-targeted drug-delivery systems in the management of kidney diseases has profound transformative potential. Kidney-targeted drug delivery can reduce the undesired side effects of often potent drugs and enhance drug efficacy in alleviating the kidney disease. Here, we review the literature on the potential strategies for targeting drugs to the kidneys. Specifically, we provide a broad overview of the targeting vectors and targeting pathways for renal tubules and glomeruli, as well as how the unique structural features of the glomerulus and the receptor-mediated internalization pathways of the tubules allows for drug targeting. Finally, we summarized the literature examples of drug delivery to the kidneys and elaborated strategies suitable for renal targeting to provide new therapeutic approaches for kidney diseases.

引用

页码：561 / 578

页数：18

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