Urocortin mRNA is expressed in the enteric nervous system of the rat

被引：65
|
作者：
Harada, S [1 ]
Imaki, T [1 ]
Naruse, M [1 ]
Chikada, N [1 ]
Nakajima, K [1 ]
Demura, H [1 ]
机构：
[1] Tokyo Womens Med Univ, Dept Med, Shinjuku Ku, Tokyo 1628666, Japan
来源：
NEUROSCIENCE LETTERS | 1999年 / 267卷 / 02期
关键词：
urocortin; corticotropin-releasing factor; enteric neuron; gastrointestinal tract; in situ hybridization;
D O I：
10.1016/S0304-3940(99)00349-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The expression of the urocortin gene in the gastrointestinal tract was investigated using reverse transcription polymerase chain reaction (RT-PCR) and in situ hybridization histochemistry. PCR demonstrated the presence of urocortin mRNA in the rat brain, duodenum, small intestine, and colon. By in situ hybridization, urocortin-containing cells were exclusively localized to the submucosal plexus and myenteric plexus in the duodenum, small intestine and colon. These results suggest that urocortin may play an important role in the regulation of gastrointestinal motor function throughout the enteric nervous system. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：125 / 128
页数：4
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