Silver-catalyzed highly efficient synthesis of pyrido[1,2-a]pyrimidin-4-ones from 2-aminopyridines and alkynoates

被引：21

作者：

Chen, Zhengwang ^{[1
]}

Wen, Yuelu ^{[1
]}

Ding, Hao ^{[1
]}

Luo, Guotian ^{[1
]}

Ye, Min ^{[1
]}

Liu, Liangxian ^{[1
]}

Xue, Jun ^{[1
]}

机构：

[1] Gannan Normal Univ, Key Lab Organopharmaceut Chem Jiangxi Prov, Ganzhou 341000, Jiangxi, Peoples R China

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 01期

关键词：

Silver-catalyzed; Pyrimidinone; Aminopyridine; Alkynoate; Cyclization; METAL-FREE; C-N; ALKYNES; DIAMINATION; DERIVATIVES; RISPERIDONE; ACCESS; AMINES;

D O I：

10.1016/j.tetlet.2016.11.079

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Pyrimidinone is one of the important nitrogen containing heterocycles due to their wide range of bioactivities. An efficient silver-catalyzed intermolecular cyclization of 2-aminopyridines with various alkynoates has been developed. 2-Substituted 4H-pyrido[1,2-a]pyrimidin-4-ones containing a wide range of functional groups are synthesized in the standard conditions. This transformation is conducted under convenient conditions and affords products in good yields. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：13 / 16

页数：4

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